Research workbench
Cohesin SMC3-HD:SCC1-N complex from yeast
Analyse Cohesin SMC3-HD:SCC1-N complex from yeast in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UX3
- Type
- protein
- Length
- 507 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosomes protein 3; Mitotic chromosome determinant-related…
- UniProt
- P47037, A6ZXW3
- Ligands
- AGS, MG
- Pockets
- 9 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Structural maintenance of chromosomes protein 3 | protein | 436 | 52% helix, 13% strand | P47037 |
| B | Mitotic chromosome determinant-related protein | protein | 71 | 61% helix, 0% strand | A6ZXW3 |
Ligands and binding sites
- AGS · Phosphothiophosphoric acid-adenylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 401 | 0.74 | 0.84 | 61 | empty |
| 2 | 69 | 0.71 | 0.95 | 18 | empty |
| 3 | 344 | 0.58 | 0.76 | 40 | empty |
| 4 | 83 | 0.53 | 0.85 | 18 | empty |
| 5 | 220 | 0.49 | 0.75 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1764 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47037
- Every structure of UniProt A6ZXW3
- Elsewhere: RCSB PDB 4UX3 · PDBe 4UX3 · UniProt P47037 · UniProt A6ZXW3
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