Research workbench
Crystal structure of the human rgma-BMP2 complex
Analyse Crystal structure of the human rgma-BMP2 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UHY
- Type
- protein
- Length
- 273 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bone morphogenetic protein 2; Repulsive guidance molecule a
- UniProt
- P12643, Q96B86
- Pockets
- 3 · best druggability 0.60
Structure
x-ray diffraction · 3 distinct chains · 28% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bone morphogenetic protein 2 | protein | 104 | 16% helix, 46% strand | P12643 |
| B | Bone morphogenetic protein 2 | protein | 105 | 16% helix, 46% strand | P12643 |
| C | Repulsive guidance molecule a | protein | 64 | 67% helix, 0% strand | Q96B86 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 265 | 0.60 | 0.79 | 44 | empty |
| 2 | 145 | 0.46 | 0.77 | 29 | empty |
| 3 | 52 | 0.26 | 0.73 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1332 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 549 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 482 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 4UHY · Crystal structure of the human RGMA-BMP2 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q96B86 · AlphaFold monomer V2.0 prediction for repulsive guidance molecule a (Q96B86) · a predicted model of the same protein · chain C against A, TM-score 0.91
- P12643 · AlphaFold monomer V2.0 prediction for bone morphogenetic protein 2 (P12643) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12643
- Every structure of UniProt Q96B86
- Elsewhere: RCSB PDB 4UHY · PDBe 4UHY · UniProt P12643 · UniProt Q96B86
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.