UniProt P12643
Bone morphogenetic protein 2 (P12643)
Bone morphogenetic protein 2 (UniProt P12643): 37 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P12643
- Protein
- Bone morphogenetic protein 2
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 6 · 0 records with a druggable one
Structures
38 records of P12643 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ES7 | Complex between bmp-2 and two bmp receptor ia ectodomains | x-ray diffraction | A, C | — | — |
| 1ES7 | Complex between bmp-2 and two bmp receptor ia ectodomains | x-ray diffraction | A, C | — | — |
| 1REU | Structure of the bone morphogenetic protein 2 mutant L51P | x-ray diffraction | A | — | — |
| 1REU | Structure of the bone morphogenetic protein 2 mutant L51P | x-ray diffraction | A | — | — |
| 1REW | Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor | x-ray diffraction | A, B | — | — |
| 1REW | Structural refinement of the complex of bone morphogenetic protein 2 and its type ia receptor | x-ray diffraction | A, B | — | — |
| 2GOO | Ternary Complex of BMP-2 bound to BMPR-Ia-ECD and ActRII-ECD | x-ray diffraction | A, D | — | — |
| 2GOO | Ternary complex of bmp-2 bound to bmpr-ia-ecd and actrii-ecd | x-ray diffraction | A, D | — | — |
| 2H62 | Crystal structure of a ternary ligand-receptor complex of BMP-2 | x-ray diffraction | A, B | — | — |
| 2H62 | Crystal structure of a ternary ligand-receptor complex of bmp-2 | x-ray diffraction | A, B | — | — |
| 2H64 | Crystal structure of a ternary ligand-receptor complex of BMP-2 | x-ray diffraction | A | — | — |
| 2H64 | Crystal structure of a ternary ligand-receptor complex of bmp-2 | x-ray diffraction | A | — | — |
| 2QJ9 | Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B1 | x-ray diffraction | B, A | — | — |
| 2QJ9 | Crystal structure analysis of bmp-2 in complex with bmpr-ia variant B1 | x-ray diffraction | B, A | — | — |
| 2QJA | Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B12 | x-ray diffraction | A, B | — | — |
| 2QJA | Crystal structure analysis of bmp-2 in complex with bmpr-ia variant B12 | x-ray diffraction | A, B | — | — |
| 2QJB | Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB | x-ray diffraction | A, B | — | — |
| 2QJB | Crystal structure analysis of bmp-2 in complex with bmpr-ia variant IA/IB | x-ray diffraction | A, B | — | — |
| 3BK3 | Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of… | x-ray diffraction | A, B | — | — |
| 3BK3 | Crystal structure of the complex of bmp-2 and the first von willebrand domain type C of… | x-ray diffraction | A, B | — | — |
| 3BMP | Human bone morphogenetic protein-2 (bmp-2) | x-ray diffraction | A | — | — |
| 3BMP | Human bone morphogenetic protein-2 (bmp-2) | x-ray diffraction | A | — | — |
| 4N1D | Nodal/BMP2 chimera NB250 | x-ray diffraction | A | — | — |
| 4N1D | NODAL/BMP2 chimera NB250 | x-ray diffraction | A | — | — |
| 4UHY | Crystal structure of the human RGMA-BMP2 complex | x-ray diffraction | A, B | — | — |
| 4UHY | Crystal structure of the human rgma-BMP2 complex | x-ray diffraction | A, B | — | — |
| 4UHZ | Crystal structure of the human RGMB-BMP2 complex, crystal form 1 | x-ray diffraction | A | — | — |
| 4UHZ | Crystal structure of the human rgmb-BMP2 complex, crystal form 1 | x-ray diffraction | A | — | — |
| 4UI0 | Crystal structure of the human RGMB-BMP2 complex, crystal form 2 | x-ray diffraction | A, B | — | — |
| 4UI0 | Crystal structure of the human rgmb-BMP2 complex, crystal form 2 | x-ray diffraction | A, B | — | — |
| 4UI1 | Crystal structure of the human RGMC-BMP2 complex | x-ray diffraction | A, B | — | — |
| 4UI1 | Crystal structure of the human rgmc-BMP2 complex | x-ray diffraction | A, B | — | — |
| 4UI2 | Crystal structure of the ternary RGMB-BMP2-NEO1 complex | x-ray diffraction | B | — | — |
| 4UI2 | Crystal structure of the ternary rgmb-BMP2-NEO1 complex | x-ray diffraction | B | — | — |
| 6OMN | Glycosylated BMP2 homodimer | x-ray diffraction | E, F, G, H | NAG, BMA, MAN | 6 (best 0.49) |
| 6OMN | Glycosylated BMP2 homodimer | x-ray diffraction | E, F, G, H | NAG, BMA, MAN | — |
| 7AG0 | Complex between the bone morphogenetic protein 2 and its antagonist noggin | x-ray diffraction | B | — | — |
| P12643 | AlphaFold monomer V2.0 prediction for bone morphogenetic protein 2 (P12643) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4N1D chain A against the predicted model Q96S42: TM-score 0.97, RMSD 0.59 Å
- 4N1D chain A against the predicted model Q96S42: TM-score 0.97, RMSD 0.59 Å
- 2H64 chain A against the predicted model P12643: TM-score 0.96, RMSD 0.77 Å
- 2H64 chain A against the predicted model P12643: TM-score 0.96, RMSD 0.77 Å
- 1REW chain A against the predicted model P12643: TM-score 0.96, RMSD 0.82 Å
- 1REW chain A against the predicted model P12643: TM-score 0.96, RMSD 0.82 Å
- 1REW chain B against the predicted model P12643: TM-score 0.95, RMSD 0.84 Å
- 1REW chain B against the predicted model P12643: TM-score 0.95, RMSD 0.84 Å
- 2GOO chain A against the predicted model P12643: TM-score 0.95, RMSD 0.84 Å
- 2GOO chain A against the predicted model P12643: TM-score 0.95, RMSD 0.84 Å
Elsewhere
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