Research workbench
Uch-L5 in complex with the RPN13 deubad domain
Analyse Uch-L5 in complex with the RPN13 deubad domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UEM
- Type
- protein
- Length
- 379 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin carboxyl-terminal hydrolase isozyme L5; Proteasomal ubiquitin receptor ADRM1
- EC
- 3.4.19.12
- UniProt
- Q9Y5K5, Q16186
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 55% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin carboxyl-terminal hydrolase isozyme L5 (EC 3.4.19.12) | protein | 281 | 51% helix, 16% strand | Q9Y5K5 |
| B | Proteasomal ubiquitin receptor ADRM1 | protein | 98 | 66% helix, 2% strand | Q16186 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.67 | 0.91 | 19 | empty |
| 2 | 145 | 0.49 | 0.78 | 24 | empty |
| 3 | 106 | 0.41 | 0.77 | 22 | empty |
| 4 | 54 | 0.27 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1901 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4UEM · UCH-L5 in complex with the RPN13 DEUBAD domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y5K5 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase isozyme L5… · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q16186 · AlphaFold monomer V2.0 prediction for proteasomal ubiquitin receptor ADRM1 (Q16186) · a predicted model of the same protein · chain B against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y5K5
- Every structure of UniProt Q16186
- Elsewhere: RCSB PDB 4UEM · PDBe 4UEM · UniProt Q9Y5K5 · UniProt Q16186
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