Research workbench
Complex of human EIF4E with the 4E binding protein 4E-BP1
Analyse Complex of human EIF4E with the 4E binding protein 4E-BP1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UED
- Type
- protein
- Length
- 213 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E; Eukaryotic translation factor 4E-binding…
- UniProt
- P06730, Q13541
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E | protein | 178 | 34% helix, 31% strand | P06730 |
| B | Eukaryotic translation factor 4E-binding protein 1 | protein | 35 | 31% helix, 0% strand | Q13541 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 191 | 0.53 | 0.78 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1256 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4UED · Complex of human eIF4E with the 4E binding protein 4E-BP1 · the same entry in another collection · chain A against A, TM-score 1.00
- P06730 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P06730) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q13541 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E-binding… · a predicted model of the same protein · chain B against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06730
- Every structure of UniProt Q13541
- Elsewhere: RCSB PDB 4UED · PDBe 4UED · UniProt P06730 · UniProt Q13541
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