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GLUA2FLIP slbd complexed with fw and (R,R)-2B crystal form F

Analyse GLUA2FLIP slbd complexed with fw and (R,R)-2B crystal form F in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4U23
Type: protein
Length: 259 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamate receptor 2,GLUTAMATE receptor 2
UniProt: P19491
Ligands: FWD, FWF
Pockets: 3 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamate receptor 2,GLUTAMATE receptor 2	protein	259	36% helix, 21% strand	P19491

Ligands and binding sites

FWD · 2-amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid · ligand · chains A
FWF · N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.68	0.97	18	FWD
2	122	0.40	0.75	21	empty
3	90	0.39	0.77	23	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4U23 · GluA2flip sLBD complexed with FW and (R,R)-2b crystal form F · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19491
Elsewhere: RCSB PDB 4U23 · PDBe 4U23 · UniProt P19491

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