Research workbench
Crystal structure analysis of the human leukotriene A4 hydrolase
Analyse Crystal structure analysis of the human leukotriene A4 hydrolase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RVB
- Type
- protein
- Length
- 607 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leukotriene a-4 hydrolase
- EC
- 3.3.2.6
- UniProt
- P09960
- Ligands
- YB, ZN
- Pockets
- 4 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leukotriene a-4 hydrolase (EC 3.3.2.6) | protein | 607 | 44% helix, 24% strand | P09960 |
Ligands and binding sites
- YB · Ytterbium (III) ion · metal · chains A
- ZN · Zinc ion · metal · chains A
- IMD · Imidazole · additive · 3 copies · chains A
- ACT · Acetate ion · additive · 2 copies · chains A
- GOL · Glycerol · additive · 2 copies · chains A
- ACY · Acetic acid · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1001 | 0.86 | 0.86 | 92 | ACT, IMD, ACY |
| 2 | 211 | 0.52 | 0.77 | 27 | empty |
| 3 | 93 | 0.51 | 0.83 | 18 | empty |
| 4 | 120 | 0.39 | 0.75 | 26 | empty |
Compared structures
- 4RVB · Crystal Structure Analysis of the Human Leukotriene A4 Hydrolase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09960
- Elsewhere: RCSB PDB 4RVB · PDBe 4RVB · UniProt P09960
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