UniProt P09960
Leukotriene A-4 hydrolase (P09960)
Leukotriene A-4 hydrolase (UniProt P09960), EC 3.3.2.6, 3.4.11.4: 131 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 90 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P09960
- Protein
- Leukotriene A-4 hydrolase
- EC
- 3.3.2.6, 3.4.11.4
- Experimental structures
- 131
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 90 · 14 records with a druggable one
Structures
132 records of P09960 in the MolNFT archive: 131 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GW6 | Structure of leukotriene A4 hydrolase D375N mutant | x-ray diffraction | A | — | — |
| 1GW6 | Structure of leukotriene A4 hydrolase D375N mutant | x-ray diffraction | A | — | — |
| 1H19 | Structure of [E271Q]LEUKOTRIENE A4 hydrolase | x-ray diffraction | A | — | — |
| 1H19 | Structure of [E271Q]LEUKOTRIENE A4 hydrolase | x-ray diffraction | A | — | — |
| 1HS6 | Structure of leukotriene A4 hydrolase complexed with bestatin. | x-ray diffraction | A | — | — |
| 1HS6 | Structure of leukotriene A4 hydrolase complexed with bestatin. | x-ray diffraction | A | — | — |
| 1SQM | Structure of [R563A] leukotriene A4 hydrolase | x-ray diffraction | A | — | — |
| 1SQM | Structure of [R563A] leukotriene A4 hydrolase | x-ray diffraction | A | — | — |
| 2R59 | Leukotriene A4 hydrolase complexed with inhibitor RB3041 | x-ray diffraction | A | — | — |
| 2R59 | Leukotriene A4 hydrolase complexed with inhibitor RB3041 | x-ray diffraction | A | — | — |
| 3B7R | Leukotriene A4 Hydrolase Complexed with Inhibitor RB3040 | x-ray diffraction | L | — | — |
| 3B7R | Leukotriene A4 hydrolase complexed with inhibitor RB3040 | x-ray diffraction | L | — | — |
| 3B7S | [E296Q]LTA4H in complex with RSR substrate | x-ray diffraction | A | — | — |
| 3B7S | [E296Q]LTA4H in complex with rsr substrate | x-ray diffraction | A | — | — |
| 3B7T | [E296Q]LTA4H in complex with Arg-Ala-Arg substrate | x-ray diffraction | A | — | — |
| 3B7T | [E296Q]LTA4H in complex with arg-ala-arg substrate | x-ray diffraction | A | — | — |
| 3B7U | Leukotriene A4 Hydrolase Complexed with KELatorphan | x-ray diffraction | X | — | — |
| 3B7U | Leukotriene A4 hydrolase complexed with kelatorphan | x-ray diffraction | X | — | — |
| 3CHO | Crystal structure of leukotriene a4 hydrolase in complex with… | x-ray diffraction | A | — | — |
| 3CHO | Crystal structure of leukotriene A4 hydrolase in complex with 2-amino… | x-ray diffraction | A | — | — |
| 3CHP | Crystal structure of leukotriene a4 hydrolase in complex with… | x-ray diffraction | A | — | — |
| 3CHP | Crystal structure of leukotriene A4 hydrolase in complex with (3S)-3… | x-ray diffraction | A | — | — |
| 3CHQ | Crystal structure of leukotriene a4 hydrolase in complex with… | x-ray diffraction | A | — | — |
| 3CHQ | Crystal structure of leukotriene A4 hydrolase in complex with N5-[4… | x-ray diffraction | A | — | — |
| 3CHR | Crystal structure of leukotriene A4 hydrolase in complex with… | x-ray diffraction | A | — | — |
| 3CHR | Crystal structure of leukotriene A4 hydrolase in complex with 4-amino… | x-ray diffraction | A | — | — |
| 3CHS | Crystal structure of leukotriene A4 hydrolase in complex with… | x-ray diffraction | A | — | — |
| 3CHS | Crystal structure of leukotriene A4 hydrolase in complex with (2S)-2… | x-ray diffraction | A | — | — |
| 3FH5 | Leukotriene A4 Hydrolase complexed with inhibitor (2R)-2-[(4-benzylphenoxy)methyl]pyrrolidine. | x-ray diffraction | A | — | — |
| 3FH5 | Leukotriene A4 hydrolase complexed with inhibitor (2R)-2-[(4- BENZYLPHENOXY)METHYL]PYRROLIDINE. | x-ray diffraction | A | — | — |
| 3FH7 | Leukotriene A4 Hydrolase complexed with inhibitor 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}pyrr… | x-ray diffraction | A | — | — |
| 3FH7 | Leukotriene A4 hydrolase complexed with inhibitor 4-[(2S)-2-{[4-(4… | x-ray diffraction | A | — | — |
| 3FH8 | Leukotriene A4 Hydrolase complexed with inhibitor 1-[2-(4-benzylphenoxy)ethyl]pyrrolidine. | x-ray diffraction | A | — | — |
| 3FH8 | Leukotriene A4 hydrolase complexed with inhibitor 1-[2-(4- BENZYLPHENOXY)ETHYL]PYRROLIDINE. | x-ray diffraction | A | — | — |
| 3FHE | Leukotriene A4 Hydrolase complexed with inhibitor N-[3-(4-benzylphenoxy)propyl]-N-methyl-beta-alanin… | x-ray diffraction | A | — | — |
| 3FHE | Leukotriene A4 hydrolase complexed with inhibitor N-[3-(4… | x-ray diffraction | A | — | — |
| 3FTS | Leukotriene A4 hydrolase in complex with resveratrol | x-ray diffraction | A | — | — |
| 3FTS | Leukotriene A4 hydrolase in complex with resveratrol | x-ray diffraction | A | — | — |
| 3FTU | Leukotriene A4 hydrolase in complex with dihydroresveratrol | x-ray diffraction | A | — | — |
| 3FTU | Leukotriene A4 hydrolase in complex with dihydroresveratrol | x-ray diffraction | A | — | — |
| 3FTV | Leukotriene A4 hydrolase in complex with fragment N-(pyridin-3-ylmethyl)aniline | x-ray diffraction | A | — | — |
| 3FTV | Leukotriene A4 hydrolase in complex with fragment N- (pyridin-3-YLMETHYL)ANILINE | x-ray diffraction | A | — | — |
| 3FTW | Leukotriene A4 hydrolase in complex with fragments N-(pyridin-3-ylmethyl)aniline and acetate | x-ray diffraction | A | — | — |
| 3FTW | Leukotriene A4 hydrolase in complex with fragments N- (pyridin-3-YLMETHYL)ANILINE and acetate | x-ray diffraction | A | — | — |
| 3FTX | Leukotriene A4 hydrolase in complex with dihydroresveratrol and bestatin | x-ray diffraction | A | — | — |
| 3FTX | Leukotriene A4 hydrolase in complex with dihydroresveratrol and bestatin | x-ray diffraction | A | — | — |
| 3FTY | Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine | x-ray diffraction | A | — | — |
| 3FTY | Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy) pyridin-2-amine | x-ray diffraction | A | — | — |
| 3FTZ | Leukotriene A4 hydrolase in complex with fragment 2-(pyridin-3-ylmethoxy)aniline | x-ray diffraction | A | — | — |
| 3FTZ | Leukotriene A4 hydrolase in complex with fragment 2-(pyridin-3- YLMETHOXY)ANILINE | x-ray diffraction | A | — | — |
| 3FU0 | Leukotriene A4 hydrolase in complex with fragment 4-(4-fluorobenzoyl)pyridine | x-ray diffraction | A | — | — |
| 3FU0 | Leukotriene A4 hydrolase in complex with fragment 4-(4- FLUOROBENZOYL)PYRIDINE | x-ray diffraction | A | — | — |
| 3FU3 | Leukotriene A4 hydrolase in complex with fragment 4-(2-amino-1,3-thiazol-4-yl)phenol | x-ray diffraction | A | — | — |
| 3FU3 | Leukotriene A4 hydrolase in complex with fragment 4-(2- amino-1,3-thiazol-4-YL)PHENOL | x-ray diffraction | A | — | — |
| 3FU5 | Leukotriene A4 hydrolase in complex with (5-thiophen-2-ylthiophen-2-yl)methylamine | x-ray diffraction | A | — | — |
| 3FU5 | Leukotriene A4 hydrolase in complex with (5-thiophen-2-ylthiophen-2- YL)METHYLAMINE | x-ray diffraction | A | — | — |
| 3FU6 | Leukotriene A4 hydrolase in complex with fragment (4-thiophen-2-ylphenyl)methanamine | x-ray diffraction | A | — | — |
| 3FU6 | Leukotriene A4 hydrolase in complex with fragment (4-thiophen-2- YLPHENYL)METHANAMINE | x-ray diffraction | A | — | — |
| 3FUD | Leukotriene A4 hydrolase in complex with N-methyl-1-(2-thiophen-2-ylphenyl)methanamine | x-ray diffraction | A | — | — |
| 3FUD | Leukotriene A4 hydrolase in complex with N-methyl-1-(2-thiophen-2- YLPHENYL)METHANAMINE | x-ray diffraction | A | — | — |
72 records more on the page itself.
Ligands
- ZN · Zinc ion · in 32 records
- YB · Ytterbium (III) ion · in 20 records
- DJ3 · 5S-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid · in 5 records
- N0Y · 1-benzyl-4-methoxybenzene · in 3 records
- 8KW · 3-[2-(2-hydroxyphenyl)ethyl]-5-methoxy-phenol · in 2 records
- BGW · 1-[[4-(1,3-benzothiazol-2-yloxy) phenyl]methyl]piperidine-4-carboxylic acid · in 2 records
- LNJ · 4-{4-[(4-methoxyphenyl)methyl]phenyl}-1,3-thiazol-2-amine · in 2 records
- RZE · (3~{S})-3-azanyl-4-[5-[4-(5-chloranyl-3-fluoranyl-pyridin-2-yl)oxyphenyl]-1,2,3,4-tetrazol-2-yl]butanoic acid · in 2 records
- RZK · 2-[5-(4-methoxyphenyl)-1,2,3,4-tetrazol-2-yl]ethanamine · in 2 records
- RZN · (4-phenoxyphenyl)methanol · in 2 records
- BGK · 4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)benzaldehyde · in 1 record
- WEE · (2R)-2-azanyl-3-[5-[4-(5-chloranyl-3-fluoranyl-pyridin-2-yl)oxyphenyl]-1,2,3,4-tetrazol-2-yl]propan-1-ol · in 1 record
- WSL · (2S)-2-azanyl-3-[5-[4-(5-chloranyl-3-fluoranyl-pyridin-2-yl)oxyphenyl]-1,2,3,4-tetrazol-2-yl]propan-1-ol · in 1 record
Experiment against prediction
- 4L2L chain A against the predicted model P09960: TM-score 0.99, RMSD 0.62 Å
- 5AEN chain A against the predicted model P09960: TM-score 0.99, RMSD 0.72 Å
- 3FTU chain A against the predicted model P09960: TM-score 0.99, RMSD 0.72 Å
- 3FTU chain A against the predicted model P09960: TM-score 0.99, RMSD 0.72 Å
- 6O5H chain A against the predicted model P09960: TM-score 0.99, RMSD 0.73 Å
- 4DPR chain A against the predicted model P09960: TM-score 0.99, RMSD 0.73 Å
- 4DPR chain A against the predicted model P09960: TM-score 0.99, RMSD 0.73 Å
- 3FU3 chain A against the predicted model P09960: TM-score 0.99, RMSD 0.73 Å
- 3FU3 chain A against the predicted model P09960: TM-score 0.99, RMSD 0.73 Å
- 6ENB chain A against the predicted model P09960: TM-score 0.99, RMSD 0.73 Å
Elsewhere
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