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Cyrstal structure of slit-robo rho GTPase-activating protein 2 fragment

Analyse Cyrstal structure of slit-robo rho GTPase-activating protein 2 fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4RUG
Type: protein
Length: 167 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Slit-robo rho GTPase-activating protein 2
UniProt: O75044
Pockets: 1 · best druggability 0.28

Structure

x-ray diffraction · 2 distinct chains · 16% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Slit-robo rho GTPase-activating protein 2	protein	86	15% helix, 37% strand	O75044
B	Slit-robo rho GTPase-activating protein 2	protein	81	16% helix, 40% strand	O75044

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.28	0.72	13	empty

Interfaces

1 interface between chains.

A–B · 347 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

4RUG · Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment · the same entry in another collection · chain A against A, TM-score 1.00
O75044 · AlphaFold monomer V2.0 prediction for slit-robo rho GTPase-activating protein 2 (O75044) · a predicted model of the same protein · chain B against A, TM-score 0.72

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75044
Elsewhere: RCSB PDB 4RUG · PDBe 4RUG · UniProt O75044

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