Structure of the bromodomain of human ATPase family aaa domain- containing protein 2 (ATAD2) complexed with histone H4-K(AC)12

Structure

x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).

Ligands and binding sites

• SO4 · Sulfate ion · ion · chains A
• EDO · 1,2-ethanediol · additive · 11 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 352 Ų buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (acetylation).

Compared structures

• 4QUT · Structure of the bromodomain of human ATPase family AAA domain-containing protein 2… · the same entry in another collection · chain A against A, TM-score 1.00
• Q6PL18 · AlphaFold monomer V2.0 prediction for ATPase family aaa domain- containing protein 2… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q6PL18
• Every structure of UniProt P62805
• Elsewhere: RCSB PDB 4QUT · PDBe 4QUT · UniProt Q6PL18 · UniProt P62805