Research workbench
Type-1 interleukin-1 receptor complexed with interleukin-1 beta
Analyse Type-1 interleukin-1 receptor complexed with interleukin-1 beta in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ITB
- Type
- protein
- Length
- 463 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-1 beta; Type 1 interleukin-1 receptor
- UniProt
- P01584, P14778
- Pockets
- 5 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-1 beta | protein | 153 | 5% helix, 44% strand | P01584 |
| B | Type 1 interleukin-1 receptor | protein | 310 | 5% helix, 40% strand | P14778 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 536 | 0.73 | 0.81 | 66 | empty |
| 2 | 219 | 0.72 | 0.88 | 29 | empty |
| 3 | 179 | 0.51 | 0.77 | 27 | empty |
| 4 | 73 | 0.35 | 0.77 | 19 | empty |
| 5 | 68 | 0.30 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1968 Ų buried · 28 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 1ITB · Type-1 interleukin-1 receptor complexed with interleukin-1 beta · the same entry in another collection · chain A against A, TM-score 1.00
- P01584 · AlphaFold monomer V2.0 prediction for interleukin-1 beta (P01584) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P14778 · AlphaFold monomer V2.0 prediction for interleukin-1 receptor type 1 (P14778) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01584
- Every structure of UniProt P14778
- Elsewhere: RCSB PDB 1ITB · PDBe 1ITB · UniProt P01584 · UniProt P14778
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