UniProt P01584
Interleukin-1 beta (P01584)
Interleukin-1 beta (UniProt P01584): 84 experimental structures and 1 predicted model on GenesisL1, 24 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01584
- Protein
- Interleukin-1 beta
- Experimental structures
- 84
- Predicted models
- 1
- Ligands
- 24
- Pockets
- 3 · 1 record with a druggable one
Structures
85 records of P01584 in the MolNFT archive: 84 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HIB | The structure of an interleukin-1 beta mutant with reduced bioactivity shows multiple subtle… | x-ray diffraction | A | — | — |
| 1HIB | The structure of an interleukin-1 beta mutant with reduced bioactivity shows multiple subtle… | x-ray diffraction | A | — | — |
| 1I1B | Crystal structure of recombinant human interleukin-1BETA at 2.0 ångströms resolution | x-ray diffraction | A | — | — |
| 1I1B | Crystal structure of recombinant human interleukin-1BETA at 2.0 ångströms resolution | x-ray diffraction | A | — | — |
| 1IOB | Interleukin-1 beta from joint X-ray and NMR refinement | x-ray diffraction, solution nmr | A | — | — |
| 1IOB | Interleukin-1 beta from joint X-ray and NMR refinement | x-ray diffraction; solution nmr | A | — | — |
| 1ITB | Type-1 interleukin-1 receptor complexed with interleukin-1 beta | x-ray diffraction | A | — | — |
| 1ITB | Type-1 interleukin-1 receptor complexed with interleukin-1 beta | x-ray diffraction | A | — | — |
| 1L2H | Crystal structure of Interleukin 1-beta F42W/W120F mutant | x-ray diffraction | A | — | — |
| 1L2H | Crystal structure of interleukin 1-beta F42W/W120F mutant | x-ray diffraction | A | — | — |
| 1S0L | Interleukin 1 beta mutant F42W | x-ray diffraction | A | — | — |
| 1S0L | Interleukin 1 beta mutant F42W | x-ray diffraction | A | — | — |
| 1T4Q | Interleukin 1 beta F101W | x-ray diffraction | A | — | — |
| 1T4Q | Interleukin 1 beta F101W | x-ray diffraction | A | — | — |
| 1TOO | Interleukin 1B Mutant F146W | x-ray diffraction | A | — | — |
| 1TOO | Interleukin 1B mutant F146W | x-ray diffraction | A | — | — |
| 1TP0 | Triple mutation in interleukin 1 beta cavity:replacement of phenylalanines with tryptophan. | x-ray diffraction | A | — | — |
| 1TP0 | Triple mutation in interleukin 1 beta CAVITY:REPLACEMENT of phenylalanines with tryptophan. | x-ray diffraction | A | — | — |
| 1TWE | Interleukin 1 beta mutant F101Y | x-ray diffraction | A | — | — |
| 1TWE | Interleukin 1 beta mutant F101Y | x-ray diffraction | A | — | — |
| 1TWM | Interleukin-1 Beta Mutant F146Y | x-ray diffraction | A | — | — |
| 1TWM | Interleukin-1 beta mutant F146Y | x-ray diffraction | A | — | — |
| 21BI | Interleukin-1 beta (il-1 beta) (mutant with cys 71 replaced by ala) (C71A) | x-ray diffraction | A | — | — |
| 21BI | Interleukin-1 beta (il-1 beta) (mutant with cys 71 replaced by ala) (C71A) | x-ray diffraction | A | — | — |
| 2I1B | Crystallographic refinement of interleukin-1 beta at 2.0 ångströms resolution | x-ray diffraction | A | — | — |
| 2I1B | Crystallographic refinement of interleukin-1 beta at 2.0 ångströms resolution | x-ray diffraction | A | — | — |
| 2KH2 | Solution structure of a scFv-IL-1B complex | solution nmr | A | — | — |
| 2KH2 | Solution structure of a scfv-il-1B complex | solution nmr | A | — | — |
| 2NVH | Determination of Solvent Content in Cavities in Interleukin-1 Using Experimentally-Phased Electron… | x-ray diffraction | A | — | — |
| 2NVH | Determination of solvent content in cavities in interleukin-1 using experimentally-phased electron… | x-ray diffraction | A | — | — |
| 31BI | Interleukin-1 beta (il-1 beta) (mutant with cys 71 replaced by ser) (C71S) | x-ray diffraction | A | — | — |
| 31BI | Interleukin-1 beta (il-1 beta) (mutant with cys 71 replaced by ser) (C71S) | x-ray diffraction | A | — | — |
| 3LTQ | Structure of Interleukin 1B solved by SAD using an inserted Lanthanide Binding Tag | x-ray diffraction | A | — | — |
| 3LTQ | Structure of interleukin 1B solved by sad using an inserted lanthanide binding tag | x-ray diffraction | A | — | — |
| 3O4O | Crystal structure of an Interleukin-1 receptor complex | x-ray diffraction | A | — | — |
| 3O4O | Crystal structure of an interleukin-1 receptor complex | x-ray diffraction | A | — | — |
| 3POK | Interleukin-1-beta LBT L3 Mutant | x-ray diffraction | A | — | — |
| 3POK | Interleukin-1-beta lbt L3 mutant | x-ray diffraction | A | — | — |
| 41BI | Interleukin-1 beta (il-1 beta) (mutant with cys 8 replaced by ala (C8A) | x-ray diffraction | A | — | — |
| 41BI | Interleukin-1 beta (il-1 beta) (mutant with cys 8 replaced by ala (C8A) | x-ray diffraction | A | — | — |
| 4DEP | Structure of the IL-1b signaling complex | x-ray diffraction | A, D | — | — |
| 4DEP | Structure of the il-1B signaling complex | x-ray diffraction | A, D | — | — |
| 4G6J | Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of… | x-ray diffraction | A | — | — |
| 4G6J | Crystal structure of human il-1BETA in complex with the therapeutic antibody binding fragment of… | x-ray diffraction | A | — | — |
| 4G6M | Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of… | x-ray diffraction | A | — | — |
| 4G6M | Crystal structure of human il-1BETA in complex with therapeutic antibody binding fragment of… | x-ray diffraction | A | — | — |
| 4I1B | Functional implications of interleukin-1BETA based on the three-dimensional structure | x-ray diffraction | A | — | — |
| 4I1B | Functional implications of interleukin-1BETA based on the three-dimensional structure | x-ray diffraction | A | — | — |
| 5BVP | The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody… | x-ray diffraction | I | — | — |
| 5I1B | A comparison of the high resolution structures of human and murine interleukin-1B | x-ray diffraction | A | — | — |
| 5I1B | A comparison of the high resolution structures of human and murine interleukin-1B | x-ray diffraction | A | — | — |
| 5R7W | Pandda analysis group deposition of ground-state model of interleukin- 1 beta | x-ray diffraction | A | SO4 | — |
| 5R85 | Pandda analysis group deposition interleukin-1 beta -- fragment Z1262246195 in complex with… | x-ray diffraction | A | SO4, S7A | — |
| 5R86 | Pandda analysis group deposition interleukin-1 beta -- fragment Z943693514 in complex with… | x-ray diffraction | A | SO4, GT4 | — |
| 5R87 | Pandda analysis group deposition interleukin-1 beta -- fragment Z44592329 in complex with… | x-ray diffraction | A | SO4, K0G | — |
| 5R88 | Pandda analysis group deposition interleukin-1 beta -- fragment Z1545313172 in complex with… | x-ray diffraction | A | SO4, LWA | — |
| 5R89 | Pandda analysis group deposition interleukin-1 beta -- fragment Z217038356 in complex with… | x-ray diffraction | A | SO4, S7D | — |
| 5R8A | Pandda analysis group deposition interleukin-1 beta -- fragment Z1492796719 in complex with… | x-ray diffraction | A | SO4, S7G | — |
| 5R8B | Pandda analysis group deposition interleukin-1 beta -- fragment Z2027049478 in complex with… | x-ray diffraction | A | SO4, K34 | — |
| 5R8C | Pandda analysis group deposition interleukin-1 beta -- fragment Z30857828 in complex with… | x-ray diffraction | A | SO4, M25 | — |
25 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 25 records
- S8D · 2-[(2~{R},5~{S})-2,5-dimethylmorpholin-4-yl]-~{N}-ethyl-ethanamide · in 2 records
- A7N · (1~{R})-1-(4-ethoxyphenyl)ethanamine · in 1 record
- GT4 · ~{N}-(4-hydroxyphenyl)-2-methoxy-ethanamide · in 1 record
- JGY · 1-methyl-N-{[(2S)-oxolan-2-yl]methyl}-1H-pyrazole-3-carboxamide · in 1 record
- K0G · N-phenyl-N'-pyridin-3-ylurea · in 1 record
- K34 · 5-(1,3-thiazol-2-yl)-1H-1,2,4-triazole · in 1 record
- K3Y · 1-methyl-3-[(3R)-piperidin-3-yl]-1H-pyrazole-4-carboxamide · in 1 record
- LWA · (2~{S})-~{N}-(4-aminocarbonylphenyl)oxolane-2-carboxamide · in 1 record
- M25 · N-{2-[4-(aminosulfonyl)phenyl]ethyl}acetamide · in 1 record
- NY4 · N-{4-[(1S)-1-aminoethyl]phenyl}cyclopropanecarboxamide · in 1 record
- OGE · 1-(5-bromanylpyridin-2-yl)-3-(2-hydroxyethyl)urea · in 1 record
- S7A · 3,3,3-tris(fluoranyl)-1-piperazin-1-yl-propan-1-one · in 1 record
- S7D · 1-[(2~{S})-2-methylmorpholin-4-yl]-2-pyrazol-1-yl-ethanone · in 1 record
- S7G · ~{N}-[(3~{R})-1,2,3,4-tetrahydroquinolin-3-yl]ethanamide · in 1 record
- S7J · 2-(trifluoromethyl)pyrimidine-5-carboxamide · in 1 record
- S7S · ~{N}-(2-ethyl-1,2,3,4-tetrazol-5-yl)butanamide · in 1 record
- S7V · [(2~{R})-4-(phenylmethyl)morpholin-2-yl]methanol · in 1 record
- S8G · 1-[(3~{R})-3-azanylpiperidin-1-yl]-4,4,4-tris(fluoranyl)butan-1-one · in 1 record
- S8J · 3-ethoxy-~{N}-(2-methyl-1,2,3,4-tetrazol-5-yl)benzamide · in 1 record
- S8P · 5-methyl-~{N}-[[(2~{S})-oxolan-2-yl]methyl]-1,2-thiazole-3-carboxamide · in 1 record
- S8V · ~{N}-[[(3~{S})-oxolan-3-yl]methyl]cyclopropanamine · in 1 record
- SX2 · 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid · in 1 record
- T91 · N-[2-(1H-benzimidazol-2-yl)ethyl]-2,2-dimethylpropanamide · in 1 record
Experiment against prediction
- 1I1B chain A against the predicted model P01584: TM-score 0.99, RMSD 0.49 Å
- 1I1B chain A against the predicted model P01584: TM-score 0.99, RMSD 0.49 Å
- 31BI chain A against the predicted model P01584: TM-score 0.99, RMSD 0.49 Å
- 31BI chain A against the predicted model P01584: TM-score 0.99, RMSD 0.49 Å
- 6Y8M chain A against the predicted model P01584: TM-score 0.99, RMSD 0.48 Å
- 5R86 chain A against the predicted model P01584: TM-score 0.99, RMSD 0.48 Å
- 41BI chain A against the predicted model P01584: TM-score 0.99, RMSD 0.50 Å
- 41BI chain A against the predicted model P01584: TM-score 0.99, RMSD 0.50 Å
- 6Y8I chain A against the predicted model P01584: TM-score 0.99, RMSD 0.48 Å
- 21BI chain A against the predicted model P01584: TM-score 0.99, RMSD 0.51 Å
Elsewhere
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