UniProt P14778
Interleukin-1 receptor type 1 (P14778)
Interleukin-1 receptor type 1 (UniProt P14778): 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 70 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P14778
- Protein
- Interleukin-1 receptor type 1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 70 · 10 records with a druggable one
Structures
11 records of P14778 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1G0Y | Il-1 receptor type 1 complexed with antagonist peptide AF10847 | x-ray diffraction | R | — | 4 (best 0.75) |
| 1G0Y | Il-1 receptor type 1 complexed with antagonist peptide AF10847 | x-ray diffraction | R | — | 4 (best 0.75) |
| 1IRA | Complex of the interleukin-1 receptor with the interleukin-1 receptor antagonist (IL1RA) | x-ray diffraction | Y | NAG | 5 (best 0.72) |
| 1IRA | Complex of the interleukin-1 receptor with the interleukin-1 receptor antagonist (IL1RA) | x-ray diffraction | Y | NAG | 5 (best 0.72) |
| 1ITB | Type-1 interleukin-1 receptor complexed with interleukin-1 beta | x-ray diffraction | B | — | 5 (best 0.73) |
| 1ITB | Type-1 interleukin-1 receptor complexed with interleukin-1 beta | x-ray diffraction | B | — | 5 (best 0.73) |
| 4DEP | Structure of the IL-1b signaling complex | x-ray diffraction | B, E | NAG | 15 (best 0.79) |
| 4DEP | Structure of the il-1B signaling complex | x-ray diffraction | B, E | NAG | 15 (best 0.79) |
| 4GAF | Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra, bound to human Interleukin-1… | x-ray diffraction | B | NAG, NA | 6 (best 0.75) |
| 4GAF | Crystal structure of ebi-005, a chimera of human il-1BETA and il-1RA, bound to human interleukin-1… | x-ray diffraction | B | NAG, NA | 6 (best 0.75) |
| P14778 | AlphaFold monomer V2.0 prediction for interleukin-1 receptor type 1 (P14778) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4GAF chain B against the predicted model P14778: TM-score 0.99, RMSD 0.72 Å
- 4GAF chain B against the predicted model P14778: TM-score 0.99, RMSD 0.72 Å
- 1ITB chain B against the predicted model P14778: TM-score 0.97, RMSD 1.22 Å
- 1ITB chain B against the predicted model P14778: TM-score 0.97, RMSD 1.22 Å
- 4DEP chain E against the predicted model P14778: TM-score 0.96, RMSD 1.38 Å
- 4DEP chain E against the predicted model P14778: TM-score 0.96, RMSD 1.38 Å
- 4DEP chain B against the predicted model P14778: TM-score 0.95, RMSD 1.53 Å
- 4DEP chain B against the predicted model P14778: TM-score 0.95, RMSD 1.53 Å
- 1IRA chain Y against the predicted model P14778: TM-score 0.85, RMSD 2.93 Å
- 1IRA chain Y against the predicted model P14778: TM-score 0.85, RMSD 2.93 Å
Elsewhere
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