Cw-type zinc finger of MORC3 in complex with the amino terminus of histone H3

Structure

x-ray diffraction · 2 distinct chains · 11% helix, 23% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 3 copies · chains A, B
• UNX · Unknown atom or ion · ion · 7 copies · chains A, B, C, D
• CL · Chloride ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

3 interfaces between chains.

• A–C · 636 Ų buried · 16 hydrogen bonds · protein-protein
• B–D · 607 Ų buried · 14 hydrogen bonds · protein-protein
• A–B · 365 Ų buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (methylation).

Compared structures

• 4QQ4 · CW-type zinc finger of MORC3 in complex with the amino terminus of histone H3 · the same entry in another collection · chain A against A, TM-score 1.00
• Q14149 · AlphaFold monomer V2.0 prediction for morc family cw-type zinc finger protein 3 (Q14149) · a predicted model of the same protein · chain A against A, TM-score 0.92
• P84243 · AlphaFold monomer V2.0 prediction for histone H3.3 (P84243) · a predicted model of the same protein · chain C against A, TM-score 0.39

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q14149
• Every structure of UniProt P84243
• Elsewhere: RCSB PDB 4QQ4 · PDBe 4QQ4 · UniProt Q14149 · UniProt P84243