Research workbench
Irs-1 ptb domain complexed with a il-4 receptor phosphopeptide, NMR, minimized average structure
Analyse Irs-1 ptb domain complexed with a il-4 receptor phosphopeptide, NMR, minimized… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1IRS
- Type
- protein
- Length
- 123 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Irs-1; Il-4 receptor phosphopeptide
- UniProt
- P35568, P24394
Structure
solution nmr · 2 distinct chains · 20% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Irs-1 | protein | 112 | 20% helix, 38% strand | P35568 |
| B | Il-4 receptor phosphopeptide | protein | 11 | 27% helix, 0% strand | P24394 |
Interfaces
1 interface between chains.
- A–B · 706 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 1IRS · Irs-1 ptb domain complexed with a il-4 receptor phosphopeptide, NMR, minimized average… · the same entry in another collection · chain A against A, TM-score 1.00
- P35568 · AlphaFold monomer V2.0 prediction for insulin receptor substrate 1 (P35568) · a predicted model of the same protein · chain A against A, TM-score 0.89
- P24394 · AlphaFold monomer V2.0 prediction for interleukin-4 receptor subunit alpha (P24394) · a predicted model of the same protein · chain B against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35568
- Every structure of UniProt P24394
- Elsewhere: RCSB PDB 1IRS · PDBe 1IRS · UniProt P35568 · UniProt P24394
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