UniProt P24394
P24394
P24394 (UniProt P24394): 14 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P24394
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 2
Structures
15 records of P24394 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IAR | Interleukin-4 / receptor alpha chain complex | x-ray diffraction | B | — | — |
| 1IAR | Interleukin-4 / receptor alpha chain complex | x-ray diffraction | B | — | — |
| 1IRS | Irs-1 ptb domain complexed with a il-4 receptor phosphopeptide, NMR, minimized average structure | solution nmr | B | — | — |
| 1IRS | Irs-1 ptb domain complexed with a il-4 receptor phosphopeptide, NMR, minimized average structure | solution nmr | B | — | — |
| 3BPL | Crystal structure of the IL4-IL4R-Common Gamma ternary complex | x-ray diffraction | B | — | — |
| 3BPL | Crystal structure of the IL4-IL4R-common gamma ternary complex | x-ray diffraction | B | — | — |
| 3BPN | Crystal structure of the IL4-IL4R-IL13Ra ternary complex | x-ray diffraction | B | — | — |
| 3BPN | Crystal structure of the IL4-IL4R-IL13RA ternary complex | x-ray diffraction | B | — | — |
| 3BPO | Crystal structure of the IL13-IL4R-IL13Ra ternary complex | x-ray diffraction | B | — | — |
| 3BPO | Crystal structure of the IL13-IL4R-IL13RA ternary complex | x-ray diffraction | B | — | — |
| 5E4E | Engineered Interleukin-13 bound to receptor | x-ray diffraction | B | NAG | — |
| 5E4E | Engineered interleukin-13 bound to receptor | x-ray diffraction | B | — | — |
| 6OEL | Engineered Fab bound to il-4 receptor | x-ray diffraction | B | NAG, FUC | — |
| 6WGL | Dupilumab Fab with crystal kappa design complexed with human il-4 receptor | x-ray diffraction | C | NAG | — |
| P24394 | AlphaFold monomer V2.0 prediction for interleukin-4 receptor subunit alpha (P24394) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6OEL chain B against the predicted model P24394: TM-score 0.99, RMSD 0.51 Å
- 3BPL chain B against the predicted model P24394: TM-score 0.98, RMSD 0.95 Å
- 3BPL chain B against the predicted model P24394: TM-score 0.98, RMSD 0.95 Å
- 5E4E chain B against the predicted model P24394: TM-score 0.97, RMSD 0.87 Å
- 5E4E chain B against the predicted model P24394: TM-score 0.97, RMSD 0.87 Å
- 1IAR chain B against the predicted model P24394: TM-score 0.97, RMSD 1.02 Å
- 1IAR chain B against the predicted model P24394: TM-score 0.97, RMSD 1.02 Å
- 3BPO chain B against the predicted model P24394: TM-score 0.96, RMSD 1.11 Å
- 3BPO chain B against the predicted model P24394: TM-score 0.96, RMSD 1.11 Å
- 3BPN chain B against the predicted model P24394: TM-score 0.96, RMSD 1.17 Å
Elsewhere
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