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Crystal structure of the tyrosine kinase domain of the human insulin receptor

Analyse Crystal structure of the tyrosine kinase domain of the human insulin receptor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IRK
Type: protein
Length: 303 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin receptor tyrosine kinase domain
UniProt: P06213
Ligands: EMC
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Insulin receptor tyrosine kinase domain	protein	303	39% helix, 17% strand	P06213

Ligands and binding sites

EMC · Ethyl mercury ion · ligand · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	368	0.64	0.79	43	empty
2	98	0.42	0.78	22	empty
3	58	0.29	0.75	17	empty

Compared structures

1IRK · Crystal structure of the tyrosine kinase domain of the human insulin receptor · the same entry in another collection · chain A against A, TM-score 1.00
P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06213
Elsewhere: RCSB PDB 1IRK · PDBe 1IRK · UniProt P06213

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