Research workbench
Crystal structure of T877A-ar-lbd bound with co-regulator peptide
Analyse Crystal structure of T877A-ar-lbd bound with co-regulator peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OH6
- Type
- protein
- Length
- 251 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Androgen receptor; Protein BUD31 homolog
- UniProt
- P10275, P41223
- Ligands
- HFT, SO4
- Pockets
- 2 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Androgen receptor | protein | 242 | 67% helix, 4% strand | P10275 |
| B | Protein BUD31 homolog | protein | 9 | 44% helix, 0% strand | P41223 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 119 | 0.81 | 0.99 | 22 | HFT |
| 2 | 157 | 0.65 | 0.86 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 528 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4OH6 · Crystal structure of T877A-AR-LBD bound with co-regulator peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P10275 · AlphaFold monomer V2.0 prediction for androgen receptor (P10275) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P41223 · AlphaFold monomer V2.0 prediction for protein BUD31 homolog (P41223) · a predicted model of the same protein · chain B against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10275
- Every structure of UniProt P41223
- Elsewhere: RCSB PDB 4OH6 · PDBe 4OH6 · UniProt P10275 · UniProt P41223
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