Research workbench
Spop promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
Analyse Spop promotes tumorigenesis by acting as a key regulatory hub in kidney cancer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4O1V
- Type
- protein
- Length
- 148 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Speckle-type poz protein; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and…
- UniProt
- O43791, P60484
Structure
x-ray diffraction · 2 distinct chains · 11% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Speckle-type poz protein | protein | 141 | 12% helix, 51% strand | O43791 |
| B | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase pten | protein | 7 | 0% helix, 14% strand | P60484 |
Interfaces
1 interface between chains.
- A–B · 418 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 4O1V · SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer · the same entry in another collection · chain A against A, TM-score 1.00
- O43791 · AlphaFold monomer V2.0 prediction for speckle-type poz protein (O43791) · a predicted model of the same protein · chain A against A, TM-score 0.94
- P60484 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 3,4,5-trisphosphate… · a predicted model of the same protein · chain B against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43791
- Every structure of UniProt P60484
- Elsewhere: RCSB PDB 4O1V · PDBe 4O1V · UniProt O43791 · UniProt P60484
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