UniProt P60484
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (P60484)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (UniProt P60484), EC 3.1.3.16, 3.1.3.48: 17 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 6…
- UniProt
- P60484
- Protein
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity…
- EC
- 3.1.3.16, 3.1.3.48, 3.1.3.67
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 6 · 3 records with a druggable one
Structures
18 records of P60484 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1D5R | Crystal Structure of the PTEN Tumor Suppressor | x-ray diffraction | A | — | — |
| 1D5R | Crystal structure of the pten tumor suppressor | x-ray diffraction | A | — | — |
| 2KYL | Solution structure of MAST2-PDZ complexed with the C-terminus of PTEN | solution nmr | B | — | — |
| 2KYL | Solution structure of MAST2-PDZ complexed with the C-terminus of pten | solution nmr | B | — | — |
| 4O1V | SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer | x-ray diffraction | B | — | — |
| 4O1V | Spop promotes tumorigenesis by acting as a key regulatory hub in kidney cancer | x-ray diffraction | B | — | — |
| 5BUG | Crystal structure of human phosphatase pten oxidized by H2O2 | x-ray diffraction | A, B, C, D | — | — |
| 5BZX | Crystal structure of human phosphatase pten treated with a bisperoxovanadium complex | x-ray diffraction | A, B, C, D | — | — |
| 5BZZ | Crystal structure of human phosphatase PTEN in its reduced state | x-ray diffraction | A, B, C, D | — | — |
| 5BZZ | Crystal structure of human phosphatase pten in its reduced state | x-ray diffraction | A, B, C, D | — | — |
| 7JUK | Crystal structure of PTEN with a tetra-phosphorylated tail (4p-crPTEN-13sp-T2, SDTTDSDPENEG) | x-ray diffraction | A | PO4 | — |
| 7JUK | Crystal structure of pten with a tetra-phosphorylated tail (4P-crpten- 13SP-T2, sdttdsdpeneg) | x-ray diffraction | A | PO4 | — |
| 7JUL | Crystal structure of non phosphorylated pten (N-crpten-13SP-T1, sdttdsdpeneg) | x-ray diffraction | A | — | — |
| 7JVX | Crystal structure of pten (aa 7-353 followed by spacer tgggsggtgggsggtgggcy ligated to peptide… | x-ray diffraction | A | PO4 | — |
| 7PC7 | The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of PTEN | x-ray diffraction | E, F | — | 1 (best 0.65) |
| 7PC7 | The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of pten | x-ray diffraction | E, F | — | — |
| 8X3S | Crystal structure of human WDR5 in complex with PTEN | x-ray diffraction | B | — | 1 (best 0.73) |
| P60484 | AlphaFold monomer V2.0 prediction for phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and… | predicted | A | — | 4 (best 0.76) |
Ligands
- PO4 · Phosphate ion · in 3 records
Experiment against prediction
- 7JUL chain A against the predicted model P60484: TM-score 0.98, RMSD 1.17 Å
- 7JVX chain A against the predicted model P60484: TM-score 0.98, RMSD 1.15 Å
- 7JUK chain A against the predicted model P60484: TM-score 0.98, RMSD 1.24 Å
- 7JUK chain A against the predicted model P60484: TM-score 0.98, RMSD 1.24 Å
- 5BUG chain A against the predicted model P60484: TM-score 0.98, RMSD 1.27 Å
- 1D5R chain A against the predicted model P60484: TM-score 0.98, RMSD 1.40 Å
- 1D5R chain A against the predicted model P60484: TM-score 0.98, RMSD 1.40 Å
- 5BZZ chain A against the predicted model P60484: TM-score 0.98, RMSD 1.31 Å
- 5BZZ chain A against the predicted model P60484: TM-score 0.98, RMSD 1.31 Å
- 5BZX chain A against the predicted model P60484: TM-score 0.97, RMSD 1.42 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.