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Crystal structure of PRO253ARG apert mutant FGF receptor 2 (FGFR2) in complex with FGF2

Analyse Crystal structure of PRO253ARG apert mutant FGF receptor 2 (FGFR2) in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IIL
Type: protein
Length: 1,361 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heparin-binding growth factor 2; Fibroblast growth factor receptor 2
EC: 2.7.1.112
UniProt: P09038, P21802
Pockets: 16 · best druggability 0.70

Structure

x-ray diffraction · 6 distinct chains · 8% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heparin-binding growth factor 2	protein	134	7% helix, 41% strand	P09038
B	Heparin-binding growth factor 2	protein	133	7% helix, 41% strand	P09038
C	Heparin-binding growth factor 2	protein	132	9% helix, 42% strand	P09038
D	Heparin-binding growth factor 2	protein	132	9% helix, 42% strand	P09038
E, F	Fibroblast growth factor receptor 2 (EC 2.7.1.112)	protein	200	10% helix, 51% strand	P21802
G, H	Fibroblast growth factor receptor 2 (EC 2.7.1.112)	protein	215	9% helix, 47% strand	P21802

Pockets

16 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	666	0.70	0.78	60	empty
2	532	0.65	0.76	60	empty
3	416	0.63	0.77	50	empty
4	490	0.63	0.76	57	empty
5	277	0.63	0.80	41	empty

Interfaces

14 interfaces between chains.

B–F · 1598 Å² buried · 21 hydrogen bonds · protein-protein
A–E · 1583 Å² buried · 22 hydrogen bonds · protein-protein
D–H · 1534 Å² buried · 22 hydrogen bonds · protein-protein
C–G · 1482 Å² buried · 22 hydrogen bonds · protein-protein
E–H · 1119 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1IIL · Crystal structure of PRO253ARG apert mutant FGF receptor 2 (FGFR2) in complex with FGF2 · the same entry in another collection · chain H against H, TM-score 1.00
P09038 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 2 (P09038) · a predicted model of the same protein · chain C against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09038
Every structure of UniProt P21802
Elsewhere: RCSB PDB 1IIL · PDBe 1IIL · UniProt P09038 · UniProt P21802

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