Research workbench
Crystal structure of SER252TRP apert mutant FGF receptor 2 (FGFR2) in complex with FGF2
Analyse Crystal structure of SER252TRP apert mutant FGF receptor 2 (FGFR2) in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1II4
- Type
- protein
- Length
- 1,336 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heparin-binding growth factor 2; Fibroblast growth factor receptor 2
- EC
- 2.7.1.112
- UniProt
- P09038, P21802
- Pockets
- 11 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Heparin-binding growth factor 2 | protein | 134 | 4% helix, 41% strand | P09038 |
| E, F, G, H | Fibroblast growth factor receptor 2 (EC 2.7.1.112) | protein | 200 | 9% helix, 51% strand | P21802 |
Pockets
11 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1072 | 0.77 | 0.79 | 125 | empty |
| 2 | 696 | 0.69 | 0.77 | 87 | empty |
| 3 | 186 | 0.60 | 0.82 | 33 | empty |
| 4 | 171 | 0.60 | 0.83 | 33 | empty |
| 5 | 153 | 0.59 | 0.84 | 23 | empty |
Interfaces
13 interfaces between chains.
- A–E · 1603 Ų buried · 20 hydrogen bonds · protein-protein
- D–H · 1596 Ų buried · 22 hydrogen bonds · protein-protein
- C–G · 1594 Ų buried · 22 hydrogen bonds · protein-protein
- B–F · 1590 Ų buried · 18 hydrogen bonds · protein-protein
- F–G · 989 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 1II4 · Crystal structure of SER252TRP apert mutant FGF receptor 2 (FGFR2) in complex with FGF2 · the same entry in another collection · chain H against H, TM-score 1.00
- P09038 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 2 (P09038) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09038
- Every structure of UniProt P21802
- Elsewhere: RCSB PDB 1II4 · PDBe 1II4 · UniProt P09038 · UniProt P21802
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.