Research workbench
Poliovirus polymerase - G289A/C290V loop mutant
Analyse Poliovirus polymerase - G289A/C290V loop mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4NLX
- Type
- protein
- Length
- 461 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase 3D-pol
- EC
- 2.7.7.48
- UniProt
- P03300
- Ligands
- NA
- Pockets
- 1 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase 3D-pol (EC 2.7.7.48) | protein | 461 | 43% helix, 15% strand | P03300 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
- ACY · Acetic acid · additive · 5 copies · chains A
- 1PE · Pentaethylene glycol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1180 | 0.71 | 0.75 | 106 | ACY |
Modifications
Observed in the structure: 3 modified (artifact).
Compared structures
- 4NLX · Poliovirus Polymerase - G289A/C290V Loop Mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03300
- Elsewhere: RCSB PDB 4NLX · PDBe 4NLX · UniProt P03300
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