Crystal structure of the complex of 3RD ww domain of human NEDD4 and 1ST ppxy motif of ARRDC3

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 31% strand (DSSP).

Ligands and binding sites

• GAI · Guanidine · ligand · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 409 Ų buried · 4 hydrogen bonds · protein-protein

Compared structures

• 4N7H · Crystal Structure of the Complex of 3rd WW domain of Human Nedd4 and 1st PPXY Motif of… · the same entry in another collection · chain A against A, TM-score 1.00
• P46934 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4 (P46934) · a predicted model of the same protein · chain A against A, TM-score 0.92
• Q96B67 · AlphaFold monomer V2.0 prediction for arrestin domain-containing protein 3 (Q96B67) · a predicted model of the same protein · chain B against A, TM-score 0.67

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P46934
• Every structure of UniProt Q96B67
• Elsewhere: RCSB PDB 4N7H · PDBe 4N7H · UniProt P46934 · UniProt Q96B67