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Crystal structure of the N-terminal ankyrin repeat domain of TRPV3
Analyse Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4N5Q
- Type
- protein
- Length
- 503 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 3
- UniProt
- Q8K424
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transient receptor potential cation channel subfamily V member 3 | protein | 249 | 54% helix, 1% strand | Q8K424 |
| B | Transient receptor potential cation channel subfamily V member 3 | protein | 254 | 55% helix, 1% strand | Q8K424 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 129 | 0.54 | 0.81 | 31 | empty |
| 2 | 76 | 0.31 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 534 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 4N5Q · Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8K424 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8K424
- Elsewhere: RCSB PDB 4N5Q · PDBe 4N5Q · UniProt Q8K424
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