Research workbench

Crystal structure of norrin in fusion with maltose binding protein

Analyse Crystal structure of norrin in fusion with maltose binding protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4MY2
Type: protein
Length: 474 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Maltose-binding periplasmic protein, norrin fusion protein
UniProt: P0AEY0, Q00604
Ligands: GLC
Pockets: 5 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Maltose-binding periplasmic protein, norrin fusion protein	protein	474	33% helix, 29% strand	P0AEY0, Q00604

Ligands and binding sites

GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	434	0.72	0.82	49	GLC
2	63	0.49	0.84	17	empty
3	57	0.33	0.77	15	empty
4	87	0.32	0.74	22	empty
5	60	0.31	0.75	14	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4MY2 · Crystal Structure of Norrin in fusion with Maltose Binding Protein · the same entry in another collection · chain A against A, TM-score 1.00
Q00604 · AlphaFold monomer V2.0 prediction for norrin (Q00604) · a predicted model of the same protein · chain A against A, TM-score 0.23

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0AEY0
Every structure of UniProt Q00604
Elsewhere: RCSB PDB 4MY2 · PDBe 4MY2 · UniProt P0AEY0 · UniProt Q00604

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.