UniProt Q00604
Norrin (Q00604)
Norrin (UniProt Q00604): 9 experimental structures and 1 predicted model on GenesisL1, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q00604
- Protein
- Norrin
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 5 · 1 record with a druggable one
Structures
10 records of Q00604 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4MY2 | Crystal Structure of Norrin in fusion with Maltose Binding Protein | x-ray diffraction | A | — | — |
| 4MY2 | Crystal structure of norrin in fusion with maltose binding protein | x-ray diffraction | A | — | — |
| 5BPU | Crystal structure of norrin, a wnt signalling activator, crystal form I | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5BQ8 | Crystal structure of norrin, a wnt signalling activator, crystal form II | x-ray diffraction | A, B, C, D | — | — |
| 5BQB | Crystal structure of norrin, a wnt signalling activator, crystal form III | x-ray diffraction | A, B, C, D | — | — |
| 5BQC | Crystal structure of norrin in complex with the cysteine-rich domain of frizzled 4 and sucrose… | x-ray diffraction | A | — | — |
| 5BQE | Crystal structure of norrin in complex with the cysteine-rich domain of frizzled 4 -methylated form | x-ray diffraction | A, B | — | — |
| 5CL1 | Complex structure of norrin with human frizzled 4 | x-ray diffraction | A, B | — | — |
| 8WVY | Cryo-EM structure of LGR4 in complex with Norrin | electron microscopy | E, F | — | 5 (best 0.64) |
| Q00604 | AlphaFold monomer V2.0 prediction for norrin (Q00604) | predicted | A | — | — |
Experiment against prediction
- 5BQE chain A against the predicted model Q00604: TM-score 0.95, RMSD 1.08 Å
- 5BQ8 chain B against the predicted model Q00604: TM-score 0.95, RMSD 1.12 Å
- 5BQ8 chain C against the predicted model Q00604: TM-score 0.94, RMSD 1.30 Å
- 5BPU chain B against the predicted model Q00604: TM-score 0.94, RMSD 1.21 Å
- 5BPU chain D against the predicted model Q00604: TM-score 0.94, RMSD 1.46 Å
- 5BQB chain B against the predicted model Q00604: TM-score 0.94, RMSD 1.27 Å
- 5BPU chain C against the predicted model Q00604: TM-score 0.93, RMSD 1.11 Å
- 5BQB chain A against the predicted model Q00604: TM-score 0.93, RMSD 1.33 Å
- 5BQC chain A against the predicted model Q00604: TM-score 0.93, RMSD 1.34 Å
- 8WVY chain E against the predicted model Q00604: TM-score 0.91, RMSD 1.45 Å
Elsewhere
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