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Human Notch1 EGF domains 11-13 mutant T466V

Analyse Human Notch1 EGF domains 11-13 mutant T466V in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4CUE
Type: protein
Length: 122 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3
Source: HOMO SAPIENS
Molecule: Neurogenic locus notch homolog protein 1
UniProt: P46531
Ligands: CA

Structure

x-ray diffraction · resolution 3 · 1 distinct chain · 6% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neurogenic locus notch homolog protein 1	protein	122	6% helix, 33% strand	P46531

Ligands and binding sites

CA · Calcium ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 9 disulfide (disulfide).

Compared structures

4CUE · Human NOTCH1 EGF domains 11-13 mutant T466V · the same entry in another collection · chain A against A, TM-score 1.00
P46531 · AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 1 (P46531) · a predicted model of the same protein · chain A against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46531
Elsewhere: RCSB PDB 4CUE · PDBe 4CUE · UniProt P46531

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