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Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic

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PDB: 3IN8
Type: protein
Length: 101 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.7
Source: Homo sapiens
Molecule: Growth factor receptor-bound protein 2
UniProt: P62993
Ligands: FYI

Structure

x-ray diffraction · resolution 1.7 · 1 distinct chain · 16% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Growth factor receptor-bound protein 2	protein	101	16% helix, 27% strand	P62993

Ligands and binding sites

FYI · N-{(2S)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-isoleucyl-L-aspartamide · ligand · chains A
FMT · Formic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

3IN8 · Crystal structure of the GRB2 SH2 domain in complex with a flexible ac-ptyr-ile-asn-NH2… · the same entry in another collection · chain A against A, TM-score 1.00
P62993 · AlphaFold monomer V2.0 prediction for growth factor receptor-bound protein 2 (P62993) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62993
Elsewhere: RCSB PDB 3IN8 · PDBe 3IN8 · UniProt P62993

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