Research workbench
Crystal structure of mutant Androgen Receptor ligand binding domain L702H/H875Y/F877L with DHT
Analyse Crystal structure of mutant Androgen Receptor ligand binding domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8FGZ
- Type
- protein
- Length
- 243 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.61
- Source
- Homo sapiens
- Molecule
- Androgen receptor
- UniProt
- P10275
- Ligands
- DHT, SO4
- Pockets
- 3 · best druggability 0.82
Structure
x-ray diffraction · resolution 1.61 · 1 distinct chain · 69% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Androgen receptor | protein | 243 | 69% helix, 5% strand | P10275 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 170 | 0.82 | 0.97 | 22 | DHT |
| 2 | 163 | 0.64 | 0.85 | 25 | SO4 |
| 3 | 81 | 0.35 | 0.75 | 14 | empty |
Compared structures
- P10275 · AlphaFold monomer V2.0 prediction for androgen receptor (P10275) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10275
- Elsewhere: RCSB PDB 8FGZ · PDBe 8FGZ · UniProt P10275
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