Research workbench

LRRC8A:C conformation 1 (round) LRR focus 3

Analyse LRRC8A:C conformation 1 (round) LRR focus 3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 8DRQ
Type: protein
Length: 407 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 4.16
Source: Mus musculus
Molecule: Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562
UniProt: Q80WG5, P0ABE7
Pockets: 3 · best druggability 0.71

Structure

electron microscopy · resolution 4.16 · 1 distinct chain · 23% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
E	Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562	protein	407	23% helix, 17% strand	Q80WG5, P0ABE7

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	67	0.71	0.96	18	empty
2	62	0.33	0.76	13	empty
3	60	0.31	0.76	16	empty

Compared structures

Q80WG5 · AlphaFold monomer V2.0 prediction for volume-regulated anion channel subunit LRRC8A… · a predicted model of the same protein · chain E against A, TM-score 0.95
P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain E against A, TM-score 0.11

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q80WG5
Every structure of UniProt P0ABE7
Elsewhere: RCSB PDB 8DRQ · PDBe 8DRQ · UniProt Q80WG5 · UniProt P0ABE7

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