UniProt Q80WG5
Volume-regulated anion channel subunit LRRC8A (Q80WG5)
Volume-regulated anion channel subunit LRRC8A (UniProt Q80WG5): 50 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 573 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q80WG5
- Protein
- Volume-regulated anion channel subunit LRRC8A
- Experimental structures
- 50
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 573 · 35 records with a druggable one
Structures
51 records of Q80WG5 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6FNW | Structure of a volume-regulated anion channel of the LRRC8 family | x-ray diffraction | A | — | 1 (best 0.36) |
| 6FNW | Structure of a volume-regulated anion channel of the LRRC8 family | x-ray diffraction | A | — | — |
| 6G8Z | Structure of the pore domain of homomeric mLRRC8A volume-regulated anion channel at 3.66 A… | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.72) |
| 6G8Z | Structure of the pore domain of homomeric MLRRC8A volume-regulated anion channel at 3.66 a… | electron microscopy | A, B, C, D, E, F | — | — |
| 6G9L | Structure of homomeric mLRRC8A volume-regulated anion channel at 5.01 A resolution | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.82) |
| 6G9L | Structure of homomeric MLRRC8A volume-regulated anion channel at 5.01 a resolution | electron microscopy | A, B, C, D, E, F | — | — |
| 6G9O | Structure of full-length homomeric mLRRC8A volume-regulated anion channel at 4.25 A resolution | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.84) |
| 6G9O | Structure of full-length homomeric MLRRC8A volume-regulated anion channel at 4.25 a resolution | electron microscopy | A, B, C, D, E, F | — | — |
| 6NZW | LRRC8A-DCPIB in MSP1E3D1 nanodisc constricted state | electron microscopy | A, B, C, D, E, F | POV, L9Y | 20 (best 0.82) |
| 6NZW | LRRC8A-dcpib in MSP1E3D1 nanodisc constricted state | electron microscopy | A, B, C, D, E, F | POV, L9Y | — |
| 6NZZ | LRRC8A-DCPIB in MSP1E3D1 nanodisc expanded state | electron microscopy | A, B, C, D, E, F | POV, L9Y | 20 (best 0.82) |
| 6NZZ | LRRC8A-dcpib in MSP1E3D1 nanodisc expanded state | electron microscopy | A, B, C, D, E, F | POV, L9Y | — |
| 6O00 | apo-LRRC8A in MSP2N2 nanodisc constricted state | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.78) |
| 6O00 | Apo-LRRC8A in MSP2N2 nanodisc constricted state | electron microscopy | A, B, C, D, E, F | — | — |
| 7M17 | SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-1) | electron microscopy | A, B, C, D, E, F | PEE, YNJ | 20 (best 0.84) |
| 7M17 | Sn-407-LRRC8A in MSP1E3D1 lipid nanodiscs (pose-1) | electron microscopy | A, B, C, D, E, F | PEE, YNJ | — |
| 7M19 | SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-2) | electron microscopy | A, B, C, D, E, F | PEE, YNJ | 20 (best 0.78) |
| 7M19 | Sn-407-LRRC8A in MSP1E3D1 lipid nanodiscs (pose-2) | electron microscopy | A, B, C, D, E, F | PEE, YNJ | — |
| 7P5V | Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.77) |
| 7P5V | Structure of homomeric LRRC8A volume-regulated anion channel in complex with synthetic nanobody SB1 | electron microscopy | A, B, C, D, E, F | — | — |
| 7P5W | Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb2 | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.81) |
| 7P5W | Structure of homomeric LRRC8A volume-regulated anion channel in complex with synthetic nanobody SB2 | electron microscopy | A, B, C, D, E, F | — | — |
| 7P5Y | Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb3 | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.82) |
| 7P5Y | Structure of homomeric LRRC8A volume-regulated anion channel in complex with synthetic nanobody SB3 | electron microscopy | A, B, C, D, E, F | — | — |
| 7P60 | Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb4… | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.85) |
| 7P60 | Structure of homomeric LRRC8A volume-regulated anion channel in complex with synthetic nanobody SB4… | electron microscopy | A, B, C, D, E, F | — | — |
| 7P6K | Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb5 | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.75) |
| 7P6K | Structure of homomeric LRRC8A volume-regulated anion channel in complex with synthetic nanobody SB5 | electron microscopy | A, B, C, D, E, F | — | — |
| 8B41 | Structure of heteromeric LRRC8A/C (1:1 co-transfected) Volume-Regulated Anion Channel in complex… | electron microscopy | A, B, C, D | — | 18 (best 0.75) |
| 8B42 | Structure of heteromeric LRRC8A/C Volume-Regulated Anion Channel. | electron microscopy | A, B, C, D | — | 18 (best 0.80) |
| 8DR8 | LRRC8A:C conformation 2 (oblong) top mask | electron microscopy | A, B, C, D, E | PEE | 20 (best 0.80) |
| 8DRA | LRRC8A:C conformation 2 (oblong) LRR mask | electron microscopy | A, B | — | 11 (best 0.76) |
| 8DRE | LRRC8A:C conformation 2 (oblong) | electron microscopy | A, B, C, D, E | PEE | 20 (best 0.76) |
| 8DRK | LRRC8A:C conformation 1 (round) top focus | electron microscopy | A, B, C, D, E | PEE | 20 (best 0.85) |
| 8DRN | LRRC8A:C conformation 1 (round) LRR focus 1 | electron microscopy | A | — | 5 (best 0.73) |
| 8DRO | LRRC8A:C conformation 1 (round) LRR focus 2 | electron microscopy | B, C | — | 7 (best 0.74) |
| 8DRQ | LRRC8A:C conformation 1 (round) LRR focus 3 | electron microscopy | E | — | — |
| 8DS3 | LRRC8A:C conformation 1 (round) | electron microscopy | A, B, C, D, E | PEE | 19 (best 0.85) |
| 8DS9 | LRRC8A:C in MSPE3D1 nanodisc top focus | electron microscopy | A, B, C, D, E | PEE | 18 (best 0.84) |
| 8DSA | LRRC8A:C in MSP1E3D1 nanodisc | electron microscopy | A, B, C, D, E | PEE | 18 (best 0.84) |
| 8F74 | LRRC8A(T48D):C conformation 2 top focus | electron microscopy | A, B, C, D, E | PEE | 20 (best 0.81) |
| 8F75 | LRRC8A(T48D):C conformation 2 LRR focus | electron microscopy | A, B | — | 6 (best 0.70) |
| 8F77 | LRRC8A(T48D):C conformation 2 top focus | electron microscopy | A, B, C, D, E | PEE | 20 (best 0.79) |
| 8F79 | LRRC8A(T48D):C conformation 2 top focus | electron microscopy | A, B, C, D, E | PEE | 19 (best 0.79) |
| 8F7B | LRRC8A(T48D):C conformation 2 top focus | electron microscopy | A, B, C, D, E | PEE | 19 (best 0.81) |
| 8F7D | LRRC8A(T48D):C conformation 2 top focus | electron microscopy | A | — | 3 (best 0.71) |
| 8F7E | LRRC8A(T48D):C conformation 2 top focus | electron microscopy | B, C | — | 8 (best 0.75) |
| 8F7J | LRRC8A(T48D):C conformation 2 top focus | electron microscopy | E | — | 3 (best 0.70) |
| 9DX7 | LRRC8A:D Conformation 1 | electron microscopy | C, A, B, D | PEE | 18 (best 0.80) |
| 9DXA | LRRC8A:D Conformation 2 | electron microscopy | A, B, C, D | PEE | 17 (best 0.81) |
| Q80WG5 | AlphaFold monomer V2.0 prediction for volume-regulated anion channel subunit LRRC8A (Q80WG5) | predicted | A | — | 5 (best 0.68) |
Ligands
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 16 records
- L9Y · 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid · in 4 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 4 records
- YNJ · 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid · in 4 records
Experiment against prediction
- 6FNW chain A against the predicted model Q80WG5: TM-score 0.99, RMSD 0.92 Å
- 6FNW chain A against the predicted model Q80WG5: TM-score 0.99, RMSD 0.92 Å
- 8F75 chain A against the predicted model Q80WG5: TM-score 0.97, RMSD 1.28 Å
- 8DRA chain A against the predicted model Q80WG5: TM-score 0.97, RMSD 1.28 Å
- 9DX7 chain D against the predicted model Q80WG5: TM-score 0.97, RMSD 1.21 Å
- 9DX7 chain C against the predicted model Q80WG5: TM-score 0.97, RMSD 1.25 Å
- 8DS9 chain A against the predicted model Q80WG5: TM-score 0.96, RMSD 1.08 Å
- 8DSA chain A against the predicted model Q80WG5: TM-score 0.96, RMSD 1.08 Å
- 8DS9 chain D against the predicted model Q80WG5: TM-score 0.96, RMSD 1.32 Å
- 8DSA chain D against the predicted model Q80WG5: TM-score 0.96, RMSD 1.32 Å
Elsewhere
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