MolNFT v1 · #149026 · protein

Structure of a volume-regulated anion channel of the LRRC8 family

6FNW · Volume-regulated anion channel subunit LRRC8A: “Structure of a volume-regulated anion channel of the LRRC8 family”. X-ray diffraction, 1 pocket (best druggability 0.36). MolNFT v1 #149026 on GenesisL1: 3D structure, binding sites…

PDB: 6FNW
Type: protein
Length: 412 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Volume-regulated anion channel subunit LRRC8A
UniProt: Q80WG5
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Volume-regulated anion channel subunit LRRC8A	protein	412	32% helix, 18% strand	Q80WG5

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	82	0.36	0.76	16	EDO

Compared structures

6FNW · Structure of a volume-regulated anion channel of the LRRC8 family · the same entry in another collection · chain A against A, TM-score 1.00
Q80WG5 · AlphaFold monomer V2.0 prediction for volume-regulated anion channel subunit LRRC8A… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q80WG5
Elsewhere: RCSB PDB 6FNW · PDBe 6FNW · UniProt Q80WG5

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