MolNFT v1 · #184884 · protein
Structure of homomeric LRRC8A volume-regulated anion channel in complex with synthetic nanobody SB2
7P5W · Volume-regulated anion channel subunit LRRC8A: “Structure of homomeric LRRC8A volume-regulated anion channel in complex with synthetic nanobody SB2”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #184884 on…
- PDB
- 7P5W
- Type
- protein
- Length
- 5,028 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Volume-regulated anion channel subunit LRRC8A; Synthetic nanobody SB2
- UniProt
- Q80WG5
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 2 distinct chains · 37% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Volume-regulated anion channel subunit LRRC8A | protein | 718 | 43% helix, 12% strand | Q80WG5 |
| K, L, G, H, I, J | Synthetic nanobody SB2 | protein | 120 | 5% helix, 45% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 599 | 0.81 | 0.86 | 58 | empty |
| 2 | 599 | 0.80 | 0.86 | 57 | empty |
| 3 | 573 | 0.80 | 0.85 | 52 | empty |
| 4 | 1087 | 0.75 | 0.78 | 90 | empty |
| 5 | 1049 | 0.75 | 0.78 | 85 | empty |
Interfaces
18 interfaces between chains.
- C–D · 2500 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 2432 Ų buried · 16 hydrogen bonds · protein-protein
- E–F · 2386 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 2316 Ų buried · 20 hydrogen bonds · protein-protein
- D–E · 2259 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 disulfide (disulfide).
Compared structures
- 7P5W · Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic… · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q80WG5
- Elsewhere: RCSB PDB 7P5W · PDBe 7P5W · UniProt Q80WG5
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