MolNFT v1 · #184883 · protein
Structure of homomeric LRRC8A volume-regulated anion channel in complex with synthetic nanobody SB1
7P5V · Volume-regulated anion channel subunit LRRC8A: “Structure of homomeric LRRC8A volume-regulated anion channel in complex with synthetic nanobody SB1”. Electron microscopy, 20 pockets (best druggability 0.77). MolNFT v1 #184883 on…
- PDB
- 7P5V
- Type
- protein
- Length
- 5,034 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Volume-regulated anion channel subunit LRRC8A; Synthetic nanobody SB1
- UniProt
- Q80WG5
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 3 distinct chains · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | Volume-regulated anion channel subunit LRRC8A | protein | 718 | 45% helix, 12% strand | Q80WG5 |
| B, D, F | Volume-regulated anion channel subunit LRRC8A | protein | 732 | 44% helix, 12% strand | Q80WG5 |
| G, H, I, J, K, L | Synthetic nanobody SB1 | protein | 114 | 5% helix, 50% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1000 | 0.77 | 0.79 | 84 | empty |
| 2 | 933 | 0.75 | 0.79 | 80 | empty |
| 3 | 940 | 0.75 | 0.79 | 75 | empty |
| 4 | 461 | 0.75 | 0.84 | 55 | empty |
| 5 | 465 | 0.75 | 0.84 | 54 | empty |
Interfaces
15 interfaces between chains.
- E–F · 2845 Ų buried · 24 hydrogen bonds · protein-protein
- C–D · 2805 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 2787 Ų buried · 22 hydrogen bonds · protein-protein
- D–E · 1985 Ų buried · 19 hydrogen bonds · protein-protein
- A–F · 1982 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 disulfide (disulfide).
Compared structures
- 7P5V · Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q80WG5
- Elsewhere: RCSB PDB 7P5V · PDBe 7P5V · UniProt Q80WG5
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