Research workbench

Heptameric Human Twinkle Helicase Clinical Variant W315L

Analyse Heptameric Human Twinkle Helicase Clinical Variant W315L in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7T8C
Type: protein
Length: 3,626 residues
Chains: 7
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 4.5
Source: Homo sapiens
Molecule: Twinkle mtDNA helicase
EC: 3.6.4.12
UniProt: Q96RR1
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · resolution 4.5 · 1 distinct chain · 36% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G	Twinkle mtDNA helicase (EC 3.6.4.12)	protein	518	36% helix, 22% strand	Q96RR1

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1017	0.82	0.83	77	empty
2	1089	0.82	0.83	85	empty
3	1014	0.81	0.82	80	empty
4	819	0.81	0.84	60	empty
5	966	0.81	0.82	75	empty

Interfaces

7 interfaces between chains.

F–G · 1202 Å² buried · 8 hydrogen bonds · protein-protein
A–G · 1202 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 1177 Å² buried · 7 hydrogen bonds · protein-protein
E–F · 1162 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 1152 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

7T8C · Heptameric human twinkle helicase clinical variant W315L · the same entry in another collection · chain G against G, TM-score 1.00
Q96RR1 · AlphaFold monomer V2.0 prediction for twinkle protein, mitochondrial (Q96RR1) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96RR1
Elsewhere: RCSB PDB 7T8C · PDBe 7T8C · UniProt Q96RR1

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