MolNFT v1 · #188032 · protein

Heptameric human twinkle helicase clinical variant W315L

7T8C · Twinkle mtdna helicase: “Heptameric human twinkle helicase clinical variant W315L”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #188032 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7T8C
Type: protein
Length: 3,626 residues
Chains: 7
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Twinkle mtdna helicase
EC: 3.6.4.12
UniProt: Q96RR1
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 1 distinct chain · 36% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G	Twinkle mtdna helicase (EC 3.6.4.12)	protein	518	36% helix, 22% strand	Q96RR1

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1017	0.82	0.83	77	empty
2	1089	0.82	0.83	85	empty
3	1014	0.81	0.82	80	empty
4	819	0.81	0.84	60	empty
5	966	0.81	0.82	75	empty

Interfaces

7 interfaces between chains.

F–G · 1202 Å² buried · 8 hydrogen bonds · protein-protein
A–G · 1202 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 1177 Å² buried · 7 hydrogen bonds · protein-protein
E–F · 1162 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 1152 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

7T8C · Heptameric Human Twinkle Helicase Clinical Variant W315L · the same entry in another collection · chain G against G, TM-score 1.00
Q96RR1 · AlphaFold monomer V2.0 prediction for twinkle protein, mitochondrial (Q96RR1) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96RR1
Elsewhere: RCSB PDB 7T8C · PDBe 7T8C · UniProt Q96RR1

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