UniProt Q96RR1
Twinkle mtDNA helicase (Q96RR1)
Twinkle mtDNA helicase (UniProt Q96RR1), EC 3.6.4.12: 4 experimental structures and 1 predicted model on GenesisL1, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96RR1
- Protein
- Twinkle mtDNA helicase
- EC
- 3.6.4.12
- Experimental structures
- 4
- Predicted models
- 1
- Pockets
- 32 · 2 records with a druggable one
Structures
5 records of Q96RR1 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7T8B | Octameric Human Twinkle Helicase Clinical Variant W315L | electron microscopy | A, B, C, D, E, F, G, H | — | 20 (best 0.82) |
| 7T8B | Octameric human twinkle helicase clinical variant W315L | electron microscopy | A, B, C, D, E, F, G, H | — | — |
| 7T8C | Heptameric Human Twinkle Helicase Clinical Variant W315L | electron microscopy | A, B, C, D, E, F, G | — | — |
| 7T8C | Heptameric human twinkle helicase clinical variant W315L | electron microscopy | A, B, C, D, E, F, G | — | — |
| Q96RR1 | AlphaFold monomer V2.0 prediction for twinkle protein, mitochondrial (Q96RR1) | predicted | A | — | 12 (best 0.80) |
Experiment against prediction
- 7T8B chain B against the predicted model Q96RR1: TM-score 0.97, RMSD 1.61 Å
- 7T8B chain B against the predicted model Q96RR1: TM-score 0.97, RMSD 1.61 Å
- 7T8C chain A against the predicted model Q96RR1: TM-score 0.96, RMSD 1.66 Å
- 7T8C chain A against the predicted model Q96RR1: TM-score 0.96, RMSD 1.66 Å
- 7T8B chain A against the predicted model Q96RR1: TM-score 0.96, RMSD 1.68 Å
- 7T8B chain A against the predicted model Q96RR1: TM-score 0.96, RMSD 1.68 Å
Elsewhere
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