Research workbench
Crystal structure of the complex between the C-terminal domain of mouse MUTYH and human PCNA
Analyse Crystal structure of the complex between the C-terminal domain of mouse MUTYH… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EFA
- Type
- protein
- Length
- 401 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.7
- Source
- Homo sapiens; Mus musculus
- Molecule
- Proliferating cell nuclear antigen; Adenine DNA glycosylase
- EC
- 3.2.2.31
- UniProt
- P12004, Q99P21
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · resolution 2.7 · 2 distinct chains · 20% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proliferating cell nuclear antigen | protein | 256 | 18% helix, 43% strand | P12004 |
| B | Adenine DNA glycosylase (EC 3.2.2.31) | protein | 145 | 23% helix, 28% strand | Q99P21 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 764 | 0.69 | 0.76 | 86 | empty |
| 2 | 127 | 0.60 | 0.85 | 30 | empty |
| 3 | 138 | 0.50 | 0.79 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 850 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7EFA · Crystal structure of the complex between the C-terminal domain of mouse mutyh and human… · the same entry in another collection · chain A against A, TM-score 1.00
- P12004 · AlphaFold monomer V2.0 prediction for proliferating cell nuclear antigen (P12004) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q99P21 · AlphaFold monomer V2.0 prediction for adenine DNA glycosylase (Q99P21) · a predicted model of the same protein · chain B against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12004
- Every structure of UniProt Q99P21
- Elsewhere: RCSB PDB 7EFA · PDBe 7EFA · UniProt P12004 · UniProt Q99P21
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