Research workbench

RNA methyltransferase METTL4

Analyse RNA methyltransferase METTL4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7CV8
Type: protein
Length: 337 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.37
Source: Arabidopsis thaliana
Molecule: Methyltransferase-like protein 2
EC: 2.1.1.-
UniProt: Q8LFA9
Ligands: SFG
Pockets: 3 · best druggability 0.75

Structure

x-ray diffraction · resolution 2.37 · 1 distinct chain · 30% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methyltransferase-like protein 2 (EC 2.1.1.-)	protein	337	30% helix, 27% strand	Q8LFA9

Ligands and binding sites

SFG · Sinefungin · ligand · chains A
GOL · Glycerol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	727	0.75	0.80	86	SFG, GOL
2	57	0.31	0.76	16	empty
3	62	0.29	0.74	19	empty

Compared structures

7CV8 · RNA methyltransferase METTL4 · the same entry in another collection · chain A against A, TM-score 1.00
Q8LFA9 · AlphaFold monomer V2.0 prediction for methyltransferase-like protein 2 (Q8LFA9) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8LFA9
Elsewhere: RCSB PDB 7CV8 · PDBe 7CV8 · UniProt Q8LFA9

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