Research workbench
Structure of CDK2/cyclin A M246Q, S247EN
Analyse Structure of CDK2/cyclin A M246Q, S247EN in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SG4
- Type
- protein
- Length
- 1,038 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.43
- Source
- Homo sapiens
- Molecule
- Cyclin-dependent kinase 2; Cyclin-A2
- EC
- 2.7.11.22
- UniProt
- P24941, P20248
- Pockets
- 13 · best druggability 0.80
Structure
x-ray diffraction · resolution 2.43 · 4 distinct chains · 50% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cyclin-dependent kinase 2 (EC 2.7.11.22) | protein | 262 | 38% helix, 12% strand | P24941 |
| B | Cyclin-A2 | protein | 258 | 64% helix, 0% strand | P20248 |
| C | Cyclin-dependent kinase 2 (EC 2.7.11.22) | protein | 261 | 36% helix, 11% strand | P24941 |
| D | Cyclin-A2 | protein | 257 | 62% helix, 0% strand | P20248 |
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 152 | 0.80 | 0.97 | 25 | empty |
| 2 | 151 | 0.78 | 0.95 | 23 | empty |
| 3 | 278 | 0.63 | 0.81 | 43 | empty |
| 4 | 309 | 0.59 | 0.78 | 40 | empty |
| 5 | 223 | 0.55 | 0.78 | 32 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1680 Ų buried · 25 hydrogen bonds · protein-protein
- C–D · 1594 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 636 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 6SG4 · Structure of CDK2/CYCLIN a M246Q, S247EN · the same entry in another collection · chain D against D, TM-score 1.00
- P20248 · AlphaFold monomer V2.0 prediction for cyclin-A2 (P20248) · a predicted model of the same protein · chain D against A, TM-score 0.99
- P24941 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 2 (P24941) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24941
- Every structure of UniProt P20248
- Elsewhere: RCSB PDB 6SG4 · PDBe 6SG4 · UniProt P24941 · UniProt P20248
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.