UniProt P20248

Cyclin-A2 (P20248)

Cyclin-A2 (UniProt P20248): 205 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 106 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P20248
Protein: Cyclin-A2
Experimental structures: 205
Predicted models: 1
Ligands: 5
Pockets: 106 · 12 records with a druggable one

Structures

206 records of P20248 in the MolNFT archive: 205 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1E9H	Thr 160 phosphorylated CDK2 - Human cyclin A3 complex with the inhibitor indirubin-5-sulphonate…	x-ray diffraction	B, D	—	—
1E9H	Thr 160 phosphorylated CDK2 - human cyclin A3 complex with the inhibitor indirubin-5-sulphonate…	x-ray diffraction	B, D	—	—
1FIN	Cyclin a-cyclin-dependent kinase 2 complex	x-ray diffraction	B, D	—	—
1FIN	Cyclin a-cyclin-dependent kinase 2 complex	x-ray diffraction	B, D	—	—
1FVV	The structure of CDK2/CYCLIN a in complex with an oxindole inhibitor	x-ray diffraction	B, D	—	—
1FVV	The structure of CDK2/CYCLIN a in complex with an oxindole inhibitor	x-ray diffraction	B, D	—	—
1GY3	pCDK2/cyclin A in complex with MgADP, nitrate and peptide substrate	x-ray diffraction	B, D	—	—
1GY3	PCDK2/CYCLIN a in complex with mgadp, nitrate and peptide substrate	x-ray diffraction	B, D	—	—
1H1P	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU2058	x-ray diffraction	B, D	—	—
1H1P	Structure of human THR160-phospho CDK2/CYCLIN a complexed with the inhibitor NU2058	x-ray diffraction	B, D	—	—
1H1Q	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6094	x-ray diffraction	B, D	—	—
1H1Q	Structure of human THR160-phospho CDK2/CYCLIN a complexed with the inhibitor NU6094	x-ray diffraction	B, D	—	—
1H1R	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086	x-ray diffraction	B, D	—	—
1H1R	Structure of human THR160-phospho CDK2/CYCLIN a complexed with the inhibitor NU6086	x-ray diffraction	B, D	—	—
1H1S	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6102	x-ray diffraction	B, D	—	—
1H1S	Structure of human THR160-phospho CDK2/CYCLIN a complexed with the inhibitor NU6102	x-ray diffraction	B, D	—	—
1H24	CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F	x-ray diffraction	B, D	—	—
1H24	CDK2/CYCLIN a in complex with a 9 residue recruitment peptide from E2F	x-ray diffraction	B, D	—	—
1H25	CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated…	x-ray diffraction	B, D	—	—
1H25	CDK2/CYCLIN a in complex with an 11-residue recruitment peptide from retinoblastoma-associated…	x-ray diffraction	B, D	—	—
1H26	CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53	x-ray diffraction	B, D	—	—
1H26	CDK2/CYCLIN a in complex with an 11-residue recruitment peptide from P53	x-ray diffraction	B, D	—	—
1H27	CDK2/CyclinA in complex with an 11-residue recruitment peptide from p27	x-ray diffraction	B, D	—	—
1H27	CDK2/CYCLIN a in complex with an 11-residue recruitment peptide from P27	x-ray diffraction	B, D	—	—
1H28	CDK2/CyclinA in complex with an 11-residue recruitment peptide from p107	x-ray diffraction	B, D	—	—
1H28	CDK2/CYCLIN a in complex with an 11-residue recruitment peptide from P107	x-ray diffraction	B, D	—	—
1JST	Phosphorylated cyclin-dependent kinase-2 bound to cyclin a	x-ray diffraction	B, D	—	—
1JST	Phosphorylated cyclin-dependent kinase-2 bound to cyclin a	x-ray diffraction	B, D	—	—
1JSU	P27(KIP1)/CYCLIN A/CDK2 complex	x-ray diffraction	B	—	—
1JSU	P27(KIP1)/CYCLIN A/CDK2 complex	x-ray diffraction	B	—	—
1OGU	Structure of human THR160-phospho CDK2/CYCLIN a complexed with a…	x-ray diffraction	B, D	—	—
1OGU	Structure of human THR160-phospho CDK2/CYCLIN a complexed with a…	x-ray diffraction	B, D	—	—
1OI9	Structure of human Thr160-phospho CDK2/cyclin A complexed with a…	x-ray diffraction	B, D	—	—
1OI9	Structure of human THR160-phospho CDK2/CYCLIN a complexed with a…	x-ray diffraction	B, D	—	—
1OIU	Structure of human Thr160-phospho CDK2/cyclin A complexed with a…	x-ray diffraction	B, D	—	—
1OIU	Structure of human THR160-phospho CDK2/CYCLIN a complexed with a…	x-ray diffraction	B, D	—	—
1OIY	Structure of human Thr160-phospho CDK2/cyclin A complexed with a…	x-ray diffraction	B, D	—	—
1OIY	Structure of human THR160-phospho CDK2/CYCLIN a complexed with a…	x-ray diffraction	B, D	—	—
1OKV	Cyclin A binding groove inhibitor H-Arg-Arg-Leu-Ile-Phe-NH2	x-ray diffraction	B, D	—	—
1OKV	Cyclin a binding groove inhibitor H-arg-arg-leu-ile-phe-NH2	x-ray diffraction	B, D	—	—
1OKW	Cyclin A binding groove inhibitor Ac-Arg-Arg-Leu-Asn-(m-Cl-Phe)-NH2	x-ray diffraction	B, D	—	—
1OKW	Cyclin a binding groove inhibitor ac-arg-arg-leu-asn-(M-cl-phe)-NH2	x-ray diffraction	B, D	—	—
1OL1	Cyclin A binding groove inhibitor H-Cit-Cit-Leu-Ile-(p-F-Phe)-NH2	x-ray diffraction	B, D	—	—
1OL1	Cyclin a binding groove inhibitor H-cit-cit-leu-ile-(P-F-phe)-NH2	x-ray diffraction	B, D	—	—
1OL2	Cyclin A binding groove inhibitor H-Arg-Arg-Leu-Asn-(p-F-Phe)-NH2	x-ray diffraction	B, D	—	—
1OL2	Cyclin a binding groove inhibitor H-arg-arg-leu-asn-(P-F-phe)-NH2	x-ray diffraction	B, D	—	—
1P5E	The structure of phospho-CDK2/cyclin A in complex with the inhibitor…	x-ray diffraction	B, D	—	—
1P5E	The structure of phospho-CDK2/CYCLIN a in complex with the inhibitor…	x-ray diffraction	B, D	—	—
1PKD	The crystal structure of ucn-01 in complex with phospho-CDK2/CYCLIN a	x-ray diffraction	B, D	—	—
1PKD	The crystal structure of ucn-01 in complex with phospho-CDK2/CYCLIN a	x-ray diffraction	B, D	—	—
1QMZ	Phosphorylated CDK2-cyclyin a-substrate peptide complex	x-ray diffraction	B, D	—	—
1QMZ	Phosphorylated CDK2-cyclyin a-substrate peptide complex	x-ray diffraction	B, D	—	—
1URC	Cyclin A binding groove inhibitor Ace-Arg-Lys-Leu-Phe-Gly	x-ray diffraction	B, D	—	—
1URC	Cyclin a binding groove inhibitor ACE-arg-lys-leu-phe-gly	x-ray diffraction	B, D	—	—
1VYW	Structure of CDK2/Cyclin A with PNU-292137	x-ray diffraction	B, D	—	—
1VYW	Structure of CDK2/CYCLIN a with pnu-292137	x-ray diffraction	B, D	—	—
2BKZ	Structure of CDK2-cyclin a with pha-404611	x-ray diffraction	B, D	—	—
2BKZ	Structure of CDK2-cyclin a with pha-404611	x-ray diffraction	B, D	—	—
2BPM	Structure of CDK2-cyclin a with pha-630529	x-ray diffraction	B, D	—	—
2BPM	Structure of CDK2-cyclin a with pha-630529	x-ray diffraction	B, D	—	—

146 records more on the page itself.

Ligands

NA · Sodium ion · in 4 records
NO3 · Nitrate ion · in 4 records
SO4 · Sulfate ion · in 3 records
MG · Magnesium ion · in 2 records
PO4 · Phosphate ion · in 1 record

Experiment against prediction

4EOR chain B against the predicted model P20248: TM-score 1.00, RMSD 0.24 Å
4EOR chain B against the predicted model P20248: TM-score 1.00, RMSD 0.24 Å
4BCP chain B against the predicted model P20248: TM-score 1.00, RMSD 0.25 Å
4BCP chain B against the predicted model P20248: TM-score 1.00, RMSD 0.25 Å
2IW8 chain B against the predicted model P20248: TM-score 1.00, RMSD 0.25 Å
2IW8 chain B against the predicted model P20248: TM-score 1.00, RMSD 0.25 Å
4BCM chain B against the predicted model P20248: TM-score 1.00, RMSD 0.25 Å
4BCM chain B against the predicted model P20248: TM-score 1.00, RMSD 0.25 Å
4EOL chain B against the predicted model P20248: TM-score 1.00, RMSD 0.25 Å
4EOL chain B against the predicted model P20248: TM-score 1.00, RMSD 0.25 Å

Elsewhere

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