Research workbench
K46bE&K114bD mutant ATP-grasp fold of Blastocystis hominis succinyl-CoA synthetase
Analyse K46bE&K114bD mutant ATP-grasp fold of Blastocystis hominis succinyl-CoA… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6NO6
- Type
- protein
- Length
- 463 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.911
- Source
- Blastocystis sp. subtype 1 (strain ATCC 50177 / NandII)
- Molecule
- Succinate--CoA ligase [ADP-forming] subunit beta
- EC
- 6.2.1.5
- UniProt
- B3FHP0
- Pockets
- 5 · best druggability 0.65
Structure
x-ray diffraction · resolution 1.911 · 2 distinct chains · 31% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) | protein | 229 | 31% helix, 31% strand | B3FHP0 |
| B | Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) | protein | 234 | 32% helix, 32% strand | B3FHP0 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 82 | 0.65 | 0.91 | 16 | empty |
| 2 | 338 | 0.62 | 0.78 | 36 | empty |
| 3 | 324 | 0.60 | 0.78 | 39 | empty |
| 4 | 74 | 0.34 | 0.76 | 15 | empty |
| 5 | 52 | 0.29 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1337 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 6NO6 · K46BE&K114BD mutant ATP-grasp fold of blastocystis hominis succinyl- CoA synthetase · the same entry in another collection · chain A against A, TM-score 1.00
- B3FHP0 · AlphaFold monomer V2.0 prediction for succinate--CoA ligase [ADP- forming] subunit beta… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B3FHP0
- Elsewhere: RCSB PDB 6NO6 · PDBe 6NO6 · UniProt B3FHP0
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