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SegA-asym, conformation of TDP-43 low complexity domain segment A asym

Analyse SegA-asym, conformation of TDP-43 low complexity domain segment A asym in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6N3B
Type: protein
Length: 385 residues
Chains: 10
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.8
Source: Homo sapiens
Molecule: TAR DNA-binding protein 43
UniProt: Q13148

Structure

electron microscopy · resolution 3.8 · 2 distinct chains · 0% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E, G, I	TAR DNA-binding protein 43	protein	36	0% helix, 39% strand	Q13148
B, D, F, H, J	TAR DNA-binding protein 43	protein	41	0% helix, 49% strand	Q13148

Interfaces

29 interfaces between chains.

B–H · 1595 Å² buried · 44 hydrogen bonds · protein-protein
B–J · 1594 Å² buried · 44 hydrogen bonds · protein-protein
F–H · 1591 Å² buried · 44 hydrogen bonds · protein-protein
D–F · 1588 Å² buried · 44 hydrogen bonds · protein-protein
A–I · 1445 Å² buried · 46 hydrogen bonds · protein-protein

Compared structures

6N3B · Sega-asym, conformation of tdp-43 low complexity domain segment a asym · the same entry in another collection · chain J against J, TM-score 1.00
Q13148 · AlphaFold monomer V2.0 prediction for tar DNA-binding protein 43 (Q13148) · a predicted model of the same protein · chain B against A, TM-score 0.31

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13148
Elsewhere: RCSB PDB 6N3B · PDBe 6N3B · UniProt Q13148

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