Research workbench
Crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer (MICU1-MICU2 heterodimer) in an apo state
Analyse Crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6LE5
- Type
- protein
- Length
- 2,217 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.1
- Source
- Homo sapiens
- Molecule
- Calcium uptake protein 1, mitochondrial; Calcium uptake protein 2, mitochondrial
- UniProt
- Q9BPX6, Q8IYU8
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · resolution 3.1 · 8 distinct chains · 54% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium uptake protein 1, mitochondrial | protein | 234 | 55% helix, 3% strand | Q9BPX6 |
| B | Calcium uptake protein 2, mitochondrial | protein | 289 | 56% helix, 6% strand | Q8IYU8 |
| C | Calcium uptake protein 2, mitochondrial | protein | 280 | 54% helix, 5% strand | Q8IYU8 |
| D | Calcium uptake protein 1, mitochondrial | protein | 304 | 52% helix, 6% strand | Q9BPX6 |
| E | Calcium uptake protein 1, mitochondrial | protein | 304 | 49% helix, 7% strand | Q9BPX6 |
| F | Calcium uptake protein 2, mitochondrial | protein | 279 | 56% helix, 5% strand | Q8IYU8 |
| G | Calcium uptake protein 1, mitochondrial | protein | 236 | 55% helix, 4% strand | Q9BPX6 |
| H | Calcium uptake protein 2, mitochondrial | protein | 291 | 57% helix, 5% strand | Q8IYU8 |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 555 | 0.75 | 0.82 | 65 | empty |
| 2 | 73 | 0.73 | 0.97 | 14 | empty |
| 3 | 67 | 0.72 | 0.97 | 13 | empty |
| 4 | 584 | 0.71 | 0.79 | 47 | empty |
| 5 | 585 | 0.70 | 0.78 | 58 | empty |
Interfaces
10 interfaces between chains.
- A–B · 1011 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 1005 Ų buried · 6 hydrogen bonds · protein-protein
- E–F · 1000 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 955 Ų buried · 11 hydrogen bonds · protein-protein
- G–H · 950 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 52 modified (engineered).
Compared structures
- 6LE5 · Crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer (MICU1-MICU2… · the same entry in another collection · chain H against H, TM-score 1.00
- Q9BPX6 · AlphaFold monomer V2.0 prediction for calcium uptake protein 1, mitochondrial (Q9BPX6) · a predicted model of the same protein · chain G against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BPX6
- Every structure of UniProt Q8IYU8
- Elsewhere: RCSB PDB 6LE5 · PDBe 6LE5 · UniProt Q9BPX6 · UniProt Q8IYU8
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