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Crystal structure of the catalytic subunit of human protein kinase CK2

Analyse Crystal structure of the catalytic subunit of human protein kinase CK2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1NA7
Type: protein
Length: 326 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.4
Source: Homo sapiens
Molecule: Casein kinase II, alpha chain
EC: 2.7.1.37
UniProt: P68400
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · resolution 2.4 · 1 distinct chain · 38% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Casein kinase II, alpha chain (EC 2.7.1.37)	protein	326	38% helix, 15% strand	P68400

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	326	0.65	0.80	40	empty
2	64	0.33	0.76	13	empty

Compared structures

1NA7 · Crystal structure of the catalytic subunit of human protein kinase CK2 · the same entry in another collection · chain A against A, TM-score 1.00
P68400 · AlphaFold monomer V2.0 prediction for casein kinase II subunit alpha (P68400) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P68400
Elsewhere: RCSB PDB 1NA7 · PDBe 1NA7 · UniProt P68400

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