UniProt P68400
Casein kinase II subunit alpha (P68400)
Casein kinase II subunit alpha (UniProt P68400), EC 2.7.11.1: 305 experimental structures and 1 predicted model on GenesisL1, 121 ligands bound, 90 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P68400
- Protein
- Casein kinase II subunit alpha
- EC
- 2.7.11.1
- Experimental structures
- 305
- Predicted models
- 1
- Ligands
- 121
- Pockets
- 90 · 16 records with a druggable one
Structures
306 records of P68400 in the MolNFT archive: 305 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JWH | Crystal Structure of Human Protein Kinase CK2 Holoenzyme | x-ray diffraction | A, B | — | — |
| 1JWH | Crystal structure of human protein kinase CK2 holoenzyme | x-ray diffraction | A, B | — | — |
| 1NA7 | Crystal structure of the catalytic subunit of human protein kinase CK2 | x-ray diffraction | A | — | — |
| 1NA7 | Crystal structure of the catalytic subunit of human protein kinase CK2 | x-ray diffraction | A | — | — |
| 1PJK | Crystal Structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit | x-ray diffraction | A | — | — |
| 1PJK | Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit | x-ray diffraction | A | — | — |
| 2PVR | Crystal structure of the catalytic subunit of protein kinase CK2 (C-terminal deletion mutant 1-335)… | x-ray diffraction | A | — | — |
| 2PVR | Crystal structure of the catalytic subunit of protein kinase CK2 (C- terminal deletion mutant… | x-ray diffraction | A | — | — |
| 2ZJW | Crystal structure of human CK2 alpha complexed with Ellagic acid | x-ray diffraction | A | — | — |
| 2ZJW | Crystal structure of human CK2 alpha complexed with ellagic acid | x-ray diffraction | A | — | — |
| 3AMY | Crystal structure of human CK2 alpha complexed with apigenin | x-ray diffraction | A | — | — |
| 3AMY | Crystal structure of human CK2 alpha complexed with apigenin | x-ray diffraction | A | — | — |
| 3AT2 | Crystal structure of CK2alpha | x-ray diffraction | A | — | — |
| 3AT2 | Crystal structure of CK2ALPHA | x-ray diffraction | A | — | — |
| 3AT3 | Crystal structure of CK2alpha with pyradine derivative | x-ray diffraction | A | — | — |
| 3AT3 | Crystal structure of CK2ALPHA with pyradine derivative | x-ray diffraction | A | — | — |
| 3AT4 | Crystal structure of CK2alpha with pyradine derivertive | x-ray diffraction | A | — | — |
| 3AT4 | Crystal structure of CK2ALPHA with pyradine derivertive | x-ray diffraction | A | — | — |
| 3AXW | Crystal structure of human CK2alpha complexed with a potent inhibitor | x-ray diffraction | A | — | — |
| 3AXW | Crystal structure of human CK2ALPHA complexed with a potent inhibitor | x-ray diffraction | A | — | — |
| 3BQC | High pH-value crystal structure of emodin in complex with the catalytic subunit of protein kinase… | x-ray diffraction | A | — | — |
| 3BQC | High pH-value crystal structure of emodin in complex with the catalytic subunit of protein kinase… | x-ray diffraction | A | — | — |
| 3C13 | Low pH-value crystal structure of emodin in complex with the catalytic subunit of protein kinase CK2 | x-ray diffraction | A | — | — |
| 3C13 | Low pH-value crystal structure of emodin in complex with the catalytic subunit of protein kinase CK2 | x-ray diffraction | A | — | — |
| 3FWQ | Inactive conformation of human protein kinase CK2 catalytic subunit | x-ray diffraction | A, B | — | — |
| 3FWQ | Inactive conformation of human protein kinase CK2 catalytic subunit | x-ray diffraction | A, B | — | — |
| 3H30 | Crystal structure of the catalytic subunit of human protein kinase CK2 with… | x-ray diffraction | A, B | — | — |
| 3H30 | Crystal structure of the catalytic subunit of human protein kinase CK2 with… | x-ray diffraction | A, B | — | — |
| 3JUH | Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity | x-ray diffraction | A, B | — | — |
| 3JUH | Crystal structure of a mutant of human protein kinase CK2ALPHA with altered cosubstrate specificity | x-ray diffraction | A, B | — | — |
| 3MB6 | Human CK2 catalytic domain in complex with a difurane derivative inhibitor (CPA) | x-ray diffraction | A | — | — |
| 3MB6 | Human CK2 catalytic domain in complex with a difurane derivative inhibitor (cpa) | x-ray diffraction | A | — | — |
| 3MB7 | Human CK2 catalytic domain in complex with a difurane derivative inhibitor (AMR) | x-ray diffraction | A | — | — |
| 3MB7 | Human CK2 catalytic domain in complex with a difurane derivative inhibitor (amr) | x-ray diffraction | A | — | — |
| 3NGA | Human CK2 catalytic domain in complex with CX-4945 | x-ray diffraction | A, B | — | — |
| 3NGA | Human CK2 catalytic domain in complex with cx-4945 | x-ray diffraction | A, B | — | — |
| 3NSZ | Human CK2 catalytic domain in complex with AMPPN | x-ray diffraction | A | — | — |
| 3NSZ | Human CK2 catalytic domain in complex with amppn | x-ray diffraction | A | — | — |
| 3PE1 | Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-4945 | x-ray diffraction | A | — | — |
| 3PE1 | Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor cx-4945 | x-ray diffraction | A | — | — |
| 3PE2 | Crystal structure of human protein kinase CK2 in complex with the inhibitor CX-5011 | x-ray diffraction | A | — | — |
| 3PE2 | Crystal structure of human protein kinase CK2 in complex with the inhibitor cx-5011 | x-ray diffraction | A | — | — |
| 3PE4 | Structure of human O-GlcNAc transferase and its complex with a peptide substrate | x-ray diffraction | B, D | — | — |
| 3PE4 | Structure of human O-glcnac transferase and its complex with a peptide substrate | x-ray diffraction | B, D | — | — |
| 3Q04 | Crystal structure of the apo-form of human CK2 alpha at pH 8.5 | x-ray diffraction | A | — | — |
| 3Q04 | Crystal structure of the apo-form of human CK2 alpha at pH 8.5 | x-ray diffraction | A | — | — |
| 3Q9W | Crystal structure of human CK2 alpha in complex with emodin at pH 8.5 | x-ray diffraction | A | — | — |
| 3Q9W | Crystal structure of human CK2 alpha in complex with emodin at pH 8.5 | x-ray diffraction | A | — | — |
| 3Q9X | Crystal structure of human CK2 alpha in complex with emodin at pH 6.5 | x-ray diffraction | A, B | — | — |
| 3Q9X | Crystal structure of human CK2 alpha in complex with emodin at pH 6.5 | x-ray diffraction | A, B | — | — |
| 3Q9Y | Crystal structure of human CK2 alpha in complex with Quinalizarin at pH 8.5 | x-ray diffraction | A | — | — |
| 3Q9Y | Crystal structure of human CK2 alpha in complex with quinalizarin at pH 8.5 | x-ray diffraction | A | — | — |
| 3Q9Z | Crystal structure of human CK2 alpha in complex with Quinalizarin at pH 6.5 | x-ray diffraction | A, B | — | — |
| 3Q9Z | Crystal structure of human CK2 alpha in complex with quinalizarin at pH 6.5 | x-ray diffraction | A, B | — | — |
| 3QA0 | Crystal structure of the apo-form of human CK2 alpha at pH 6.5 | x-ray diffraction | A, B | — | — |
| 3QA0 | Crystal structure of the apo-form of human CK2 alpha at pH 6.5 | x-ray diffraction | A, B | — | — |
| 3R0T | Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-5279 | x-ray diffraction | A | — | — |
| 3R0T | Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor cx-5279 | x-ray diffraction | A | — | — |
| 3RPS | Structure of human CK2alpha in complex with the ATP-competitive inhibitor… | x-ray diffraction | A, B | — | — |
| 3RPS | Structure of human CK2ALPHA in complex with the ATP-competitive inhibitor… | x-ray diffraction | A, B | — | — |
246 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 55 records
- CL · Chloride ion · in 30 records
- PO4 · Phosphate ion · in 22 records
- NA · Sodium ion · in 17 records
- ADP · Adenosine-5'-diphosphate · in 14 records
- ATP · Adenosine-5'-triphosphate · in 12 records
- MG · Magnesium ion · in 12 records
- E3U · (6AR)-3,4,6A,10-tetrakis(oxidanyl)-6,7-dihydroindeno[2, 1-c]chromen-9-one · in 6 records
- IHP · Inositol hexakisphosphate · in 6 records
- 9YE · 4-(3-methylbut-2-enoxy)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione · in 4 records
- CIY · (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal · in 4 records
- FER · 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid · in 4 records
- FXB · 5-propan-2-yl-4-prop-2-enoxy-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione · in 4 records
- V55 · 4-hydroxy-3-methoxybenzaldehyde · in 4 records
- 7EY · 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid · in 3 records
- 7FC · 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid · in 3 records
- A8Q · [3-chloranyl-4-(2-propan-2-ylphenyl) phenyl]methylazanium · in 3 records
- GJK · (~{E})-4-(3-methoxy-4-oxidanyl-phenyl)but-3-en-2-one · in 3 records
- 42J · 2-(3,4-dichlorophenyl)ethanamine · in 2 records
- 4IH · ~{N}-[3-[(3-chloranyl-4-phenyl-phenyl) methylamino]propyl]methanesulfonamide · in 2 records
- 5ID · (2R,3R,4S,5R)-2-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3, 4-diol · in 2 records
- 6XK · ~{N}-[2-[(1~{S},2~{S})-2-(aminomethyl)cyclopropyl]-5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]phenyl]ethanamide · in 2 records
- 6XT · ~{N}-[5-[[7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methyl-phenyl]ethanamide · in 2 records
- 86L · (3-chloranyl-4-propan-2-yloxy-phenyl)methanamine · in 2 records
- 8GQ · pyrazolo-pyrimidine macrocycle · in 2 records
- 8QH · (4~{Z})-6,7-bis(chloranyl)-4-[[(4-methylphenyl) amino]methylidene]-8-oxidanyl-1,2-dihydrodibenzofuran-3-one · in 2 records
- AU8 · [3,5-bis(chloranyl)-4-phenyl-phenyl]methylazanium · in 2 records
- AUT · [3,5-bis(chloranyl)-4-(2-ethylphenyl)phenyl]methanamine · in 2 records
- AUW · 2-(1~{H}-benzimidazol-2-yl)-~{N}-[[3,5-bis(chloranyl)-4-(2-ethylphenyl)phenyl]methyl]ethanamine · in 2 records
- B0K · 3-[4,5,6,7-tetrakis(bromanyl)benzimidazol-1-yl]propan-1-amine · in 2 records
Experiment against prediction
- 3NGA chain A against the predicted model P68400: TM-score 1.00, RMSD 0.37 Å
- 3NGA chain A against the predicted model P68400: TM-score 1.00, RMSD 0.37 Å
- 8P06 chain B against the predicted model P68400: TM-score 1.00, RMSD 0.40 Å
- 5H8B chain A against the predicted model P68400: TM-score 1.00, RMSD 0.41 Å
- 5N1V chain B against the predicted model P68400: TM-score 1.00, RMSD 0.42 Å
- 5N1V chain B against the predicted model P68400: TM-score 1.00, RMSD 0.42 Å
- 7AY9 chain A against the predicted model P68400: TM-score 1.00, RMSD 0.43 Å
- 7AY9 chain A against the predicted model P68400: TM-score 1.00, RMSD 0.43 Å
- 3U87 chain A against the predicted model P68400: TM-score 1.00, RMSD 0.44 Å
- 3U87 chain A against the predicted model P68400: TM-score 1.00, RMSD 0.44 Å
Elsewhere
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