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Ligand · RFZ

RFZ · 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole

RFZ, 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole (C12 H12 Cl2 N2 O4, 319.1 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
RFZ
Formula
C12 H12 Cl2 N2 O4
Class
ligand
Structures
6
PDB entries
3

Binding sites

RFZ in 6 structures; the first of them:

  • 3H30 · Crystal structure of the catalytic subunit of human protein kinase CK2 with… · RFZ A336 · binds LEU45, GLY46, ARG47, VAL53, VAL66, ILE95, VAL116, ASN117 and 3 more
  • 3MY1 · Structure of CDK9/cyclinT1 in complex with DRB · RFZ A336 · binds ILE25, GLY26, PHE30, VAL33, ALA46, LYS48, VAL79, PHE103 and 7 more
  • 3MY5 · CDk2/cyclinA in complex with DRB · RFZ A300 · binds ILE10, GLY11, GLU12, GLY13, GLY16, VAL18, ALA31, LYS33 and 7 more
  • 3H30 · Crystal structure of the catalytic subunit of human protein kinase CK2 with… · RFZ A336 · binds LEU45, GLY46, ARG47, VAL53, VAL66, ILE95, VAL116, ASN117 and 3 more
  • 3MY1 · Structure of CDK9/CYCLINT1 in complex with drb · RFZ A336 · binds ILE25, GLY26, PHE30, VAL33, ALA46, LYS48, VAL79, PHE103 and 7 more
  • 3MY5 · CDK2/CYCLINA in complex with drb · RFZ A300 · binds ILE10, GLY11, GLU12, GLY13, GLY16, VAL18, ALA31, LYS33 and 7 more

Residues it binds most

VAL 12, ILE 12, LEU 12, GLY 8, PHE 6, ASN 8, ASP 8, ALA 8, GLN 6, GLU 4 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion
  • PO4 · Phosphate ion
  • FMT · Formic acid
  • GOL · Glycerol
  • SGM · Monothioglycerol

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