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Structure of SUR1 subunit bound with repaglinide

Analyse Structure of SUR1 subunit bound with repaglinide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6JB3
Type: protein
Length: 671 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.53
Source: Mesocricetus auratus
Molecule: ATP-binding cassette sub-family C member 8 isoform X2
UniProt: A0A1U7R319
Ligands: BJX, AJP
Pockets: 7 · best druggability 0.84

Structure

electron microscopy · resolution 3.53 · 1 distinct chain · 88% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	ATP-binding cassette sub-family C member 8 isoform X2	protein	671	88% helix, 0% strand	A0A1U7R319

Ligands and binding sites

BJX · Repaglinide · ligand · chains B
AJP · Digitonin · ligand · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	859	0.84	0.86	89	BJX, AJP
2	188	0.53	0.78	29	empty
3	127	0.50	0.80	28	empty
4	126	0.45	0.77	24	empty
5	98	0.43	0.78	15	empty

Compared structures

6JB3 · Structure of SUR1 subunit bound with repaglinide · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1U7R319
Elsewhere: RCSB PDB 6JB3 · PDBe 6JB3 · UniProt A0A1U7R319

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