MolNFT v1 · #153327 · protein
Structure of SUR1 subunit bound with repaglinide
6JB3 · ATP-binding cassette sub-family C member 8 isoform X2: “Structure of SUR1 subunit bound with repaglinide”. Electron microscopy, 2 ligands (BJX, AJP), 7 pockets (best druggability 0.84). MolNFT v1 #153327 on GenesisL1: 3D structure…
- PDB
- 6JB3
- Type
- protein
- Length
- 671 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-binding cassette sub-family C member 8 isoform X2
- UniProt
- A0A1U7R319
- Ligands
- BJX, AJP
- Pockets
- 7 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 88% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | ATP-binding cassette sub-family C member 8 isoform X2 | protein | 671 | 88% helix, 0% strand | A0A1U7R319 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 859 | 0.84 | 0.86 | 89 | BJX, AJP |
| 2 | 188 | 0.53 | 0.78 | 29 | empty |
| 3 | 127 | 0.50 | 0.80 | 28 | empty |
| 4 | 126 | 0.45 | 0.77 | 24 | empty |
| 5 | 98 | 0.43 | 0.78 | 15 | empty |
Compared structures
- 6JB3 · Structure of SUR1 subunit bound with repaglinide · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1U7R319
- Elsewhere: RCSB PDB 6JB3 · PDBe 6JB3 · UniProt A0A1U7R319
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